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1、FEBSLetters585(2011)797–802journalhomepage:www.FEBSLetters.orgCandidaalbicansZcf37,azincfingerprotein,isrequiredforstabilizationofthewhitestate11⇑HuafengWang,WenjiSong,GuanghuaHuang,ZhouZhou,YufengDing,JiangyeChenStateKeyLaboratoryofMolecularBiology,Institu
2、teofBiochemistryandCellBiology,SIBS,ChineseAcademyofSciences,320YueYangRoad,Shanghai200031,ChinaarticleinfoabstractArticlehistory:Candidaalbicans,themostprevalenthumanfungalpathogen,canswitchstochasticallybetweenReceived1October2010whiteandopaquephases.Int
3、hisstudy,weidentifiedZcf37,azincfingerprotein,asanewregulatorRevised31December2010ofwhite-opaqueswitching.DeletionofZCF37increasedwhite-to-opaqueswitchingfrequencyandAccepted4February2011stabilizedtheopaquestate.OverexpressionofZCF37promotedconversionofopaqu
4、ecellstowhiteAvailableonline11February2011phase,butneededexistenceofEfg1,akeyregulatorrequiredformaintenanceofthewhitestate.DeletionofEFG1abolishedtheeffectofectopicallyexpressedZcf37onopaque-to-whiteswitching,EditedbyJuditOvádiwhereasectopicexpressionofEF
5、G1promotedwhitecellformationwithoutpresenceofZcf37.OurresultssuggestthatZcf37actsasanactivatorofwhitecellformationandarepressorofopaquestateKeywords:andfunctionsupstreamofEfg1.Zcf37RegulatorÓ2011FederationofEuropeanBiochemicalSocieties.PublishedbyElsevierB
6、.V.Allrightsreserved.White-opaqueswitchingCandidaalbicans1.IntroductionplayingoppositeroletoWor1[9–11].EFG1ishighlyexpressedinwhitecells,butisrepressedinopaquecells.DeletionofEFG1pro-Asacommensalandapathogenofhumanbeings,Candidaalbicansmotesopaquecellforma
7、tionandoverexpressionofEFG1forcesdevelopsabilitytoundergoyeast-to-hyphatransitionandhigh-fre-opaquecellstoswitchtowhiteform.Czf1andWor2,twozincfin-quencyphenotypicswitchingthatprovidestheorganismwithhighgerproteinsenrichedinopaquecells,playpositiverolesinre
8、gula-adaptabilitynecessarytosurviveindifferenthostniches[1].Oneoftionofwhite-to-opaqueswitching[11–13].Inopaquecells,Wor1thehigh-frequencyswitchingsystemsiswhite-opaqueswitchingcanbindtothepromotersofallfoura
