2型糖尿病患者血清sclerositn和dkk1水平与骨密度相关性分析

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1、英文摘要mellitus．Dataregardingthispathwayindiabetesmellitusarelimitedtoanimalmodelsandhavefocusedontheanalysisofgeneexpressionorconcentrationofthemajorproteinsintheboneenvironment．However，toourknowledge，nostudieshadbeenconductedinhumansandmorespecificallyinT2DM．Inthiscontext，theobjectives

2、ofourstudyweretoevaluateserumsclerostinanddkkllevelsinT2DMpatientsandtoanalyzeitsrelationshipswithboneBMDandrelatedclinicalfactors，SOthatwecantoprovidecertainrbasisforthestudyoftherelationshipbetweenT2DMandosteopsorosis，forclinicaltrialsinthetreatmentofosteoporosiswithDKK1，Sclerostina

3、ntibodies。Methods：Atotalof105T2DMinpatientswereincludedinTheThirdHospitalofHebeiMedicalUniversityEndocrinologyDepartmentfromJune2013toDecember2013．AllsubjectsweremeasuredBMDatL2一L4lumbarvertebrae，bothfemurs(neck，greattrochanter,intertrochanter)byDEXA．Accordingtothediagnosticcriteria(D

4、EXA)oftheAmericanassociationofosteoporosis，theWHO，theEuropeanassociationofosteoporosisandbonedisease．,，allsubjectsweredividedintonormalgroup，bonebonelossgroupandosteoporosisgroup．Werecordthegender，age，height，weight，durationandotherrelatedinformationofpatients，calculatebodymassindex，an

5、dmeasurefastingbloodglucose(FBG)，glycosylatedhemoglobin(HbAlc)，triglycerides(TG)，cholesterol(TC)，high-densitylipoprotein(HDL—O，lowdensitylipoprotein(LDL—C)andotherbiochemicalindicators，usingenzyme—linkedimmunosorbentmethod(enzyme—linkedimmunosorbentassay，ELISA)toevaluationserumscleros

6、tinandDKK1level．Alldatawereshowby(i士SD)andwereanalyzedusingSPSSl3．0．Results：1ffhemultipleregressionanalysisbetweenBMDandage，gender,B—MI，glycosylatedhemoglobin，duration：AgewasnegativelycorrelatedwithdoublehipandL2BMD，sexwasnegativelycorrelatedwithL3，Rneckbonedensity．4英文摘要2Therewerenosi

7、gnificantcorrelationbetweenbonemineraldensityandage，gendegBMI，course，glycosylatedhemoglobin，multipleofthreegroupsregressionanalysis．3DKK1andsclerostinlevelwasstatisticallysignificantbetweenthreegroupsp<0．05)．4TheanalysisofDKK1andsclerostinlevelscorrelationwithage，gender,course，glycosy

8、lated