Nature Reviews Drug Discovery 2012.02.pdf

《Nature Reviews Drug Discovery 2012.02.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、INTHISISSUEecentadvancesinRNAbiologyhaveacceleratedtheprogressofanewgenerationofmoleculartherapiesbasedonRNA,withRseveralagentsnowinadvancedclinicaltrials.InourfirstReview,KoleandcolleaguescompareandcontrastthemechanismsofactionandeffectsofthreeRNA-basedtherapeutictec

2、hnologies—RNAinterference,antisenseoligonucleotidesandsteric-blockingoligonucleotides—anddiscusstheirprogressinthetreatmentofneuromusculardiseases,bacterialandviralinfections,hypercholesterolaemiaandcancer.Ahallmarkoftumourcellsisanintrinsicoracquiredresistancetoapopt

3、osis.RNA-basedtherapeuticsp125Thisevasionofcelldeathisoftenaidedbytheabnormalexpressionofmembersofafamilyofanti-apoptoticproteinsknownastheinhibitorofapoptosis(IAP)proteins,whichhavebeenlinkedtotumourprogression,treatmentfailureandpoorprognosisinvariouscancers.Intheir

4、Review,FuldaandVucicprovideanoverviewofIAPbiologyanddiscussthetherapeuticstrategiesthatarebeingdevelopedtotargetIAPproteinsinhumanmalignancies.OurfinalReviewthismonthcomprehensivelydiscussescognitivedysfunctioninpatientswithpsychiatricdisorders,whichiscommonandseverel

5、ycompromisesthequalityoflifeofpatientsbutislargelynotaddressedbyexistingtreatmentsthatfocusonemotionalCognitioninpsychiatricdisordersp141symptomssuchasdepressionandanxiety.Millanandcolleaguessummarizethecharacteristicsofcognitivedysfunctionaswellasthecerebralandcellul

6、arnetworksintegratingandmodulatingcognitionthataredisruptedinpsychiatricdisorders.Theyalsocriticallyanalysecurrentandemergingstrategiesforimprovingcognitioninpatientssufferingfromsuchdiseases,andconsiderkeychallengessuchasthedevelopmentofmoreeffectivetranslationalrese

7、archapproaches.EDITORIALOFFICEManagingproductioneditor:JudithShadwellEDITORSLondonNatureReviews@nature.comSeniorproductioneditor:SimonFenwickTheMacmillanBuilding,4CrinanStreet,productioncontroLLer:NatalieSmithLondonN19XW,UKSenioreditoriaLaSSiStant:LauraCornsTel:+44(0)

8、2078433620;editoriaLaSSiStant:EllaLinesFax:+44(0)2078433629webproductionManager:DeborahAnthonyMarketingManagerS:TimRedding,V