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ID:34564495
大小:3.99 MB
页数:39页
时间:2019-03-08
《神经生长因子控释凝胶促进大鼠周围神经损伤后再生的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、摘要目的:运用纤维蛋白胶(FG)结合神经生长因子(NGF)包裹SD大鼠坐骨神经断端,通过纤维蛋白胶控释NGF以促进神经纤维再生并减少神经吻合口瘢痕形成。方法:SD大鼠24只,随机分为2组,每组12只。A组:大鼠坐骨神经切断后神经外膜直接缝合,然后吻合口包裹FG/NC,F凝胶,B组:神经外膜直接缝合,吻合口未包裹凝胶。分别于术后第l、3、5、7周行术侧足迹实验检测,术后2月行术侧三头肌湿重恢复率测量、电生理测定、甲苯胺蓝染色、透射电镜分析等。结果:同一时间段两组间比较,各指标A组明显好于B组。结论:NGF缓释凝胶可以促进大鼠坐骨神经离断损伤的修复
2、并防止吻合口与肄围组织粘连。关键词:神经生长因子;纤维蛋白凝胶;周围神经;损伤;再生StudyofRepairofPeripheralNerveDefectwithControlReleasedNGFinRatsAbstractObjective:ToevaluatetheeffectofthecontrolledreleaseofbiodegradableFG,nervegrowthfactor(FG/NGF)onperipheralnervedefect.Methods:towenty-fourSprague2Dawlyratswerera
3、ndomlydividedintotwogroups,FG/NGF(groupA,n:12),Stitchingofcombine(groupB,n212).Eachratunderwentrightsciaticnervecutingintotwopieces,thenthesedefectswererepairedinthetwodifferentexperimentalgroups.Theprocessoftheperipheralnerveregenerationwasevaluatedat2monthsfollowingoperati
4、on,andtheevaluateditemswerefootprintingtest,gicepsweight,electrophysiological,Immunohistochemistr,Methylene,Bluetrihydmteaxonmorphologicassessmentoftheoutcomeofnerveregeneration.Results:NerveregenerationingroupAwascomparablewiththatseeninnatuaiNerveandWassignificantlysuperio
5、rtothatinBgroupsinallindexes.Conclusion::FG/NGFcontrolledreleasewasapotentialideal,thatcaneffectivelypromotenerveregenerationaftersciaticnervedefectofrets.TheeffectWasasgoodasthatofnatualNerve.Keywords:NGF;FG;Peripheralnerve;Nervedefect;RgenerationDirectedby:prof.Ao0iangAppI
6、icantForMasterDegree:WangLBng(DepartmentofneurosurgeD,)(CollegeofMongolianMedicineandPharmacy,InnerMongoliaUniversityforNationalities.Tonglia028043.chma)目录1前言⋯⋯⋯⋯...⋯⋯....⋯⋯.......⋯⋯⋯..........⋯.⋯⋯⋯⋯11.1论文研究的目的⋯⋯⋯⋯⋯.⋯⋯⋯..⋯⋯⋯⋯⋯⋯⋯⋯.22实验材料与实验方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯.22.1实验材料及实验方法⋯⋯
7、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯22.2实验所用动物及手术方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯.32.3实验检测方法⋯⋯⋯.⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯33实验结果与疗效分析⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯.63.1术后伤口及患肢大体观察⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯.63.2足迹试验⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..73.3肌肉湿重比测定⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯.83.4神经电生理测定....⋯⋯...⋯⋯.⋯⋯⋯.............⋯....93.5组织形态学评价⋯⋯.⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯lo3.
8、5.1免疫组织化学⋯⋯.⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯lo3.5.2甲苯胺蓝染色⋯⋯.⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯113.5.3坐骨神经超薄切片
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