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1、Volume1,Issue1,March–April2010;Article015HOLLOWMICROSPHERE:AREVIEWS.B.Gholap*,S.K.Banarjee,D.D.Gaikwad,S.L.Jadhav,R.M.ThoratVishalInstituteofPharmaceuticalEducationandResearch,Ale,Pune-412411.*E-mail:rupali.78@rediffmail.comABSTRACTThepurposeofwritingthisreviewonHollowmicrosp
2、heresistocompiletherecentliteraturewithspecialfocusontheprincipalmechanismoffloatationtoachievegastricretention.Hollowmicrospherepromisestobeapotentialapproachforgastricretention.TherecentdevelopmentsofFDDSincludingapproachestodesignsingle-unitandmultiple-unitfloatingsystems,
3、mechanismoffloatingmicrospheres,methodsofpreparationofhollowmicrosphere,listofpolymersusedinhollowmicrospheres,characterizationofhollowmicrospheres,andtheirclassificationandformulationaspectsarecoveredindetail.Key-words:GRDFs,FDDS,HollowMicrospheresINTRODUCTIONTheseconsiderat
4、ionshaveledtothedevelopmentoforalcontrolledrelease(CR)dosageformspossessinggastricThegoalofanydrugdeliverysystemistoprovidearetentioncapabilities.Drugmaynotbeabsorbeduniformlytherapeuticamountofdrugtothepropersiteinthebodytooverthelengthofthegastrointestinaltract,becausedosag
5、eachievepromptlyandthenmaintainthedesireddrug1formmayberapidlytransportedfrommoreabsorptiveconcentration.Themostconvenientandcommonlyupperregionsoftheintestinetolowerregionswheretheemployedrouteofdrugdeliveryhashistoricallybeenby2drugislessabsorbedanddrugabsorptionfromcolonis
6、oralingestion.usuallyerraticandinefficient.Moreover,certaindrugsareDrugsthatareeasilyabsorbedfromtheGITandhavingaabsorbedonlyfromthestomachortheupperpartofsmall5shorthalf-lifeareeliminatedquicklyfromthebloodintestine.circulation.Toavoidtheseproblemsoralcontrolleddrug6,7APPROA
7、CHESTOGASTRICRETENTION:deliverysystemshavebeendevelopedastheyreleasesthedrugslowlyintotheGITandmaintainaconstantdrugAnumberofapproacheshavebeenusedtoincreaseconcentrationintheserumforlongerperiodoftime.gastricretentiontime(GRT)ofadosageforminstomachbyemployingavarietyofconcep
8、ts.Theseincludesinfig.However,incompletereleaseofthedrugandashorter1
