资源描述：
《40.In vitro degradation of porous poly l-lactide-co-glycolide -tricalcium phosphate PLGA-TCP scaffolds under dynamic and static conditions.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、PolymerDegradationandStability93(2008)1838–1845ContentslistsavailableatScienceDirectPolymerDegradationandStabilityjournalhomepage:www.elsevier.com/locate/polydegstabInvitrodegradationofporouspoly(L-lactide-co-glycolide)/b-tricalciumphosphate(PLGA/b-TCP)scaffoldsunderdy
2、namicandstaticconditionsaaaaa,*b,*YanfangYang,YunhuiZhao,GongwenTang,HuaLi,XiaoyanYuan,YuboFanaSchoolofMaterialsScienceandEngineering,TianjinKeyLaboratoryofCompositeandFunctionalMaterials,TianjinUniversity,Tianjin300072,ChinabDepartmentofBioengineering,BeihangUniversit
3、y,XueyuanRoad37#,HaidianDistrict,Beijing100083,ChinaarticleinfoabstractArticlehistory:Invitrodegradationofporouspoly(L-lactide-co-glycolide)/b-tricalciumphosphate(PLGA/b-TCP)scaffoldsReceived23March2008wasstudiedbyincubatingthesamplesinphosphatebufferedsaline(PBS)at37
4、CandpH7.4underReceivedinrevisedform6July2008dynamicloadingwithrespecttostaticconditionsfor12weeks.Underdynamicconditions,acidityofPBSAccepted8July2008wasalleviatedbythebettersolutioncirculation,andwaterabsorptionofthescaffoldsincreasedmoreAvailableonline18July2008thant
5、hatunderstaticconditionsinthefirst8weeks.Changesinmass,height,diameter,relativemolecularmassanditsdistributionalsohappenedmoreremarkablyunderdynamicconditions.Keywords:Moreover,obviouscracksandalargeramountofb-TCPparticleswereobservedonthewalloftheScaffoldscaffoldsafter
6、degradationfor12weeksunderdynamicloading.CompressivemodulusandstrengthPLGAb-TCPshowedanincreasefromthebeginningtothe10thweekbutwerelowerafterthen.ResultsshowedthatDegradationdegradationofPLGA/b-TCPscaffoldsunderdynamicconditionsexhibitedasignificantlyfasterratethanCycli
7、cloadingthatunderstaticconditions.Ó2008ElsevierLtd.Allrightsreserved.1.IntroductionThereweremanyreportsonthedegradationofPLGAscaffoldsinvivoorinvitro.TheseresultsshowedthatporousPLGAscaffoldsAsoneofthreefactorsintissueengineering,theporousscaffoldwithlowerrelativemolec
8、ularmass,highercontentofglycolide,playsaveryimportantrole[1].Thematerialusedtofabricatelowerporositiesandlargerporesw
