香菇多糖在结直肠癌患者术后辅助化疗中的应用_马云

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1、第31卷第3期中华中医药学刊Vol．31No．32013年3月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEMar．2013香菇多糖在结直肠癌患者术后辅助化疗中的应用马云，赵贤宝(义乌市中心医院肿瘤科，浙江义乌322000)摘要:目的:探讨FOLFOX4方案单独化疗与香菇多糖注射液联合FOLFOX4化疗治疗结直肠癌患者的疗效与不良反应。方法:78例结直肠癌患者，随机分为对照组37例和治疗组41例，治疗组给予香菇多糖注射液联合FOLFOX4方案化疗，对照组给予FOLFOX4方案单独化疗。监测治疗

2、前后中医症候疗效、生活质量评分、免疫功能变化及不良反应，并评价疗效。结果:治疗组和对照组的有效率和临床获益率比较，差异无统计学意义(P＞+++0.05)。治疗后的中医征候疗效及KPS评分治疗组明显高于对照组(P＜0．05)。治疗组治疗后CD3、CD4、CD4/++CD8及NK细胞比例明显增高，而CD8百分率明显降低，差异具有统计学意义(P＜0．05)。治疗组胃肠道反应、骨髓抑制、肝功能损害及周围神经毒性等不良事件的发生率低于对照组，差异有统计学意义。结论:香菇多糖注射液联合FOLFOX4方案治疗结直肠癌患者，可以提高化疗疗效，改善患

3、者生活质量，提高机体免疫功能，减轻化疗所致的不良反应，明显起到辅助、增效作用。关键词:香菇多糖;结直肠癌;FOLFOX4;化疗;免疫功能中图分类号:R735．3文献标志码:B文章编号:1673－7717(2013)03－0691－04ClinicalObservationofLentinanInjectionCombinedwithChemotherapyinTreatmentofColorectalCancerMAYun，ZHAOXianbao(YiwuCenterHospital，Yiwu322000，Zhejiang，Chin

4、a)Abstract:Objective:TocomparetheefficacyandtoxicitybetweenchemotherapyofFOLFOX4andLentinaninjectioncombinedwithFOLFOX4chemotherapytotreatpatientswithcolorectalcancer．Methods:Seventy－eightpatientswererandomlydividedintotwogroups，controlgroup(37cases)andtrearmentgroup(4

5、1cases)．Thecontrolgroupwastrea-tedwithFOLFOX4only，andtreatmentgroupwastreatedbycombiningLentinaninjectionandFOLFOX4．Thetherapeu-ticefficacywasevaluatedandKPSscoreandsideeffectswereobserved．SyndromescoresoftraditionalChinesemedicineandimmunestatuswerealsodetermined．Resu

6、lts:Therewasnodifferenceintheobjectiveresponseratebetweenthetreat-mentgroupandthecontrolgroup(P＞0．05)．KPSscoreandsyndromescoresoftraditionalChinesemedicineofthetreatmentgroupafterthetreatmentwassignificantlyhigherthanthethatofthecontrolgroup(P＜0．05)．Theimmunolog-++++ic

7、alfunctiondetectionshowedthatCD3，CD4，CD4/CD8，NKcellincreasedobviouslypost－therapythanpretherapyin+thetreatmentgroup(P＜0．05)andCD8decreasedaftertreatment(P＜0．05)．Theincidenceofgastrointestinalreac-tion，bloodtoxicity，liverdysfunctionandperipheralnervetoxicityintreatmentg

8、roupwaslessthanthoseinthecontrolgroup，thedifferenceswerestatisticallysignificant(P＜0．05)．Conclusion:Thestudysuggestst