槲寄生中的化学成分及其抗肿瘤活性(ⅰ)

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1、万方数据天然产物研究与开发肋tProd肠Dev2009。21：44l444，452文章编号：1001-688012009}03-0441-05槲寄生中的化学成分及其抗肿瘤活性【I)陈柏年，李建宽，杨宫娥+，李青山山西医科大学药学院中药学教研室，太原030001摘要：从槲寄生75％乙醇提取物中分离得到4个化合物，应用波谱学方法鉴定它们的结构为尼克酰胺(1)，乙酰胺(2)，齐墩果酸(3)，口．香树脂醇乙酸酯(4)。其中，化合物1和2为首次从槲寄生属植物中分离得到。采用MTr法对化合物1—4进行体外抗肿瘤活性研究，结果显示化合物1、2和4对H0-8910人卵巢浆液性腺癌、SMMC7721人肝癌、T

2、24人膀胱癌、HepG2人肝癌和SHG人神经胶质瘤细胞系没有细胞毒活性，化合物3则对这五种肿瘤细胞系有显著的抑制作用。关键词：槲寄生；尼克酰胺；齐墩果酸；抗肿瘤；MTT法中图分类号：Q58；R284．2文献标识码：AChemicalConstituentsfromViscumcoloratum(Kom．)NakaiandTheirAntitumorActivities(I)CHENBai—nian，LIJian—kuan，YANGGuan—e+，LIQing-shanDepartmentofTraditionalChineseMedicine，SchoolofPharmaceuticalSc

3、iences，ShanxiMedicalUniversity，Taiyuan030001，ChinaAbstract：Fourchemicalconstituentswereisolatedfromthe75％ethanolextractofViscumcoloratum(Kom．)Nakaiandtheirstructureswereidentified鹊nicotinamide(1)，aeetamide(2)，oleanolicacid(3)，肛锄徊nacetate(4)byspectralmethods．Theantitumoractivitiesofcompounds14werest

4、udiedbyMTTmethod讯vitro．Compounds1，2and4showednocytotoxicactivitiesagainstHO-8910humanovary昵rouBadenoearcinoma．SMMC7721humanhepatoma；T24humanbladdercancer；HepG2humanhepatomaandSHGhumangliomacelllines，andcompound3showedsignificantinhibitoryactivitiesagainstthosefivehumantumorcelllines．．Keywords：V／scu

5、mcoloratura(Kom．)Nakai；nicofinamide；oleanolicacid；antitumor；M1-I'IntroductionThemistletoeisaperennialsemiparasiticdwarfshrub，whichcontainsaboutmorethan30species，ofwhich1growinChina。¨．Since1920s，themistletoehasbeenusedforthetreatmentofcancers，suchasbreastCallC—er，gastriccancer，rectalcancer，etc[刘．Wit

6、hthedevel．opmentofcomplementaryoralternativemedicine(CAM)aroundtheworld，thepreparationsmadefrommistletoealebecomingmorepopular．Itisestimatedthattheyearlyexpenditureforthesepreparationsis0．ver$30millioninGermanyalonewithanannualin—ReceivedOctober15，2007；AcceptedJanuary16，2008FoundationItem：Thisworkw

7、assupportedbytheNationalNaturalSci—enceFoundationofChina(30672621)。ShamdProvineialNaturalSci-enceFoundation(20060l1099)andShanx／MedicalUniversity2007StudentInnovationFund．·CorrespondingauthorTel：86-351-4690