组蛋白去乙酰化酶2激活糖原合酶激酶3β磷酸化tau蛋白

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1、分类号学号M201074878学校代码10487密级硕士学位论文组蛋白去乙酰化酶2激活糖原合酶激酶3β磷酸化tau蛋白学位申请人：汤惠学科专业：病理学与病理生理学指导教师：朱铃强副教授答辩日期：2013年1月4日ADissertationSubmittedinPartialFulfillmentoftheRequirementsfortheDegreeofMasterHistonedeacetylase-2inducestauhyperphosphorylationviaactivationofGSK

2、-3βCandidate:HuiTangMajor:PathologyandPathophysiologySupervisor:Prof.Ling-QiangZhuHuazhongUniversityofScienceandTechnologyWuhan,Hubei430074,P.R.ChinaJan,2013独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文

3、的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框

4、内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日主要英文缩略词HDAC2Histonedeacetyltransferase2组蛋白去乙酰化酶-2GSK-3GlycogenSynthaseKinase-3糖原合酶激酶-3ADAlzheimer’sdisease阿尔茨海默病IFImmunofluorescence免疫荧光WBWesternblot蛋白免疫印迹PKAProteinkinaseA蛋白激酶APKCProteinkinaseC蛋白激酶CPP2AProteinPhosphata

5、se2A蛋白磷酸酯酶-2ACDK5CyclinDependentKinase5细胞周期蛋白依赖激酶5ERKExtracellularRegulatedprotein细胞外调节蛋白激酶KinasePTENPhosphataseandTensinhomolog磷酸酶和张力蛋白同源物目录摘要····································································································1Abstract·

6、·································································································3前言····································································································5材料与方法···············································

7、············································7结果································································································18讨论································································································28下一步工作设想及

8、要解决的问题·······························································31参考文献1···························································································32综述··························································