From single-cell to cell-pool transcriptomes Stochasticity in gene expression and RNA splicing.pdf

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1、Downloadedfromgenome.cshlp.orgonFebruary6,2014-PublishedbyColdSpringHarborLaboratoryPressFromsingle-celltocell-pooltranscriptomes:StochasticityingeneexpressionandRNAsplicingGeorgiK.Marinov,BrianA.Williams,KenMcCue,etal.GenomeRes.publishedonlineDecember3,2013Accessthemostrecentve

2、rsionatdoi:10.1101/gr.161034.113Supplementalhttp://genome.cshlp.org/content/suppl/2014/01/06/gr.161034.113.DC1.htmlMaterialP

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4、ofthearticleorclickhere.Advanceonlinearticleshavebeenpeerreviewedandacceptedforpublicationbuthavenotyetappearedinthepaperjournal(edited,typesetversionsmaybepostedwhenavailablepriortofinalpublication).Advanceonlinearticlesarecitableandestablishpublicationpriority;theyareindexedby

5、PubMedfrominitialpublication.CitationstoAdvanceonlinearticlesmustincludethedigitalobjectidentifier(DOIs)anddateofinitialpublication.TosubscribetoGenomeResearchgoto:http://genome.cshlp.org/subscriptions©2014Marinovetal.;PublishedbyColdSpringHarborLaboratoryPressDownloadedfromgeno

6、me.cshlp.orgonFebruary6,2014-PublishedbyColdSpringHarborLaboratoryPressMethodFromsingle-celltocell-pooltranscriptomes:StochasticityingeneexpressionandRNAsplicing1,41,4123GeorgiK.Marinov,BrianA.Williams,KenMcCue,GaryP.Schroth,JasonGertz,31,5RichardM.Myers,andBarbaraJ.Wold12Divisi

7、onofBiology,CaliforniaInstituteofTechnology,Pasadena,California91125,USA;Illumina,Inc.,Hayward,California94545,3USA;HudsonAlphaInstituteforBiotechnology,Huntsville,Alabama35806,USASingle-cellRNA-seqmammaliantranscriptomestudiesareatanearlystageinuncoveringcell-to-cellvariationin

8、geneexpression,transcriptprocessingandediting,a