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1、InducedPluripotentStemCellsGeneratedfromPatientswithALSCanBeDifferentiatedintoMotorNeuronsJohnT.Dimosetal.Science321,1218(2008);DOI:10.1126/science.1158799Thiscopyisforyourpersonal,non-commercialuseonly.Ifyouwishtodistributethisarticletoothers,youcano
2、rderhigh-qualitycopiesforyourcolleagues,clients,orcustomersbyclickinghere.Permissiontorepublishorrepurposearticlesorportionsofarticlescanbeobtainedbyfollowingtheguidelineshere.Thefollowingresourcesrelatedtothisarticleareavailableonlineatwww.sciencemag
3、.org(thisinformationiscurrentasofApril28,2013):Updatedinformationandservices,includinghigh-resolutionfigures,canbefoundintheonlineonApril28,2013versionofthisarticleat:http://www.sciencemag.org/content/321/5893/1218.full.htmlSupportingOnlineMaterialcan
4、befoundat:http://www.sciencemag.org/content/suppl/2008/07/31/1158799.DC1.htmlAlistofselectedadditionalarticlesontheScienceWebsitesrelatedtothisarticlecanbefoundat:http://www.sciencemag.org/content/321/5893/1218.full.html#relatedwww.sciencemag.orgThisa
5、rticlecites26articles,5ofwhichcanbeaccessedfree:http://www.sciencemag.org/content/321/5893/1218.full.html#ref-list-1Thisarticlehasbeencitedby279article(s)ontheISIWebofScienceThisarticlehasbeencitedby100articleshostedbyHighWirePress;see:http://www.scie
6、ncemag.org/content/321/5893/1218.full.html#related-urlsDownloadedfromThisarticleappearsinthefollowingsubjectcollections:Developmenthttp://www.sciencemag.org/cgi/collection/developmentScience(printISSN0036-8075;onlineISSN1095-9203)ispublishedweekly,exc
7、eptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenueNW,Washington,DC20005.Copyright2008bytheAmericanAssociationfortheAdvancementofScience;allrightsreserved.ThetitleScienceisaregisteredtrademarkofAAAS.REPORTSInd
8、ucedPluripotentStemCellswithin1weekhundredsofcoloniescomposedofrapidlydividingcellswithagranularmorpholo-gynotcharacteristicofEScellshadappeared(6).GeneratedfromPatientswithALSCanHowever,2weekslater,asmallnumberofcolo-nieswithanEScellmorpholog
