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ID:34190005
大小:4.41 MB
页数:41页
时间:2019-03-03
《降钙素对去卵巢sd大鼠骨微损伤及生物力学的影响》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、万方数据EffectofcalcitoninonbonemicrodamageandbiomechanicsAbstractinovariectomizedSDratObjective:ToexploreeffectsofCalcitoninonbonemicrodamageandbiomechanicsinovariectomizedSpargue—Dawleyrats.Methods:70female44一week-oldSpargue-Dawleyratswererandomlydividedintofourgroups:10ratsinbasel
2、inegroup(BS),20ratsinsham—operated(SHAM),20ratsinovariectomizedgroup(OVX)and20ratsinovariectomized+calcitoningroup(OVX+C),Thebaselinegroupwerekilledatthebeginningoftheexperiment.Atthe4rd,12thweekafteroperationtheratswerekilledrespectively.The4thvertebraewereusedforfatiguedamagete
3、stbyPLD5010bonefatigueexperimentdevice.Theparametersoflinearmicrocrackweremeasuredandtherightfemurwereusedforthree-pointbendingtests.Results:Microdamagecouldbeviewedineverysample,includingmicrocrack,fewcross—hatchingmicrodamage,diffusedamageandmicrofracture.microcrackwasthemostus
4、ualmicrodamagetype.At4thweek,Significantdifferenceofmicrocrackparameters(Meanmicrocracklength,Microcracksurfacedensity,Microcrackdensity)ofvertebraewasobservedbetweenOVXgroupandSHAMgroup(P<0.05),OVXgroupandOVX+Cgroup(P<0.05),alsobetweenOVX+CandSHAMgroup(P5、ignificantdifferenceofmicrocrackparametersofvertebraewasobservedbetweenOVXgroupandSHAMgroup(P<0.05),alsobetweenOVXgroupandOVX+Cgroup(P0.05).Thereisnosignificantdifferenceofbiomechanicsparametersofthefightfemurineachgroupat4thand12thweek(P>06、.05).Conclusion:CalcitonincallimprovebonemicrostructureofvertebraeandthereisnosignificanteffectonbiomechanicsofthefemurinovariectomizedSpargue-Dawleyrats.ThemicrocrackparametersCanbeconsideredalternativeparametersintheevaluationofbonemicrostructurequality.keywords:osteoporosis;ca7、lcitonin;microdamage;biomechanicsClassification:R589.1V万方数据目录学位论文原创性声明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯I中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯II英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..IV目录⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VI中英文名词及缩略语表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VII第一章前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..1第二章材料8、与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯32.1主要材料及设备⋯
5、ignificantdifferenceofmicrocrackparametersofvertebraewasobservedbetweenOVXgroupandSHAMgroup(P<0.05),alsobetweenOVXgroupandOVX+Cgroup(P0.05).Thereisnosignificantdifferenceofbiomechanicsparametersofthefightfemurineachgroupat4thand12thweek(P>0
6、.05).Conclusion:CalcitonincallimprovebonemicrostructureofvertebraeandthereisnosignificanteffectonbiomechanicsofthefemurinovariectomizedSpargue-Dawleyrats.ThemicrocrackparametersCanbeconsideredalternativeparametersintheevaluationofbonemicrostructurequality.keywords:osteoporosis;ca
7、lcitonin;microdamage;biomechanicsClassification:R589.1V万方数据目录学位论文原创性声明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯I中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯II英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..IV目录⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VI中英文名词及缩略语表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VII第一章前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..1第二章材料
8、与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯32.1主要材料及设备⋯
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