降钙素对去卵巢sd大鼠骨微损伤及生物力学的影响

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1、万方数据EffectofcalcitoninonbonemicrodamageandbiomechanicsAbstractinovariectomizedSDratObjective：ToexploreeffectsofCalcitoninonbonemicrodamageandbiomechanicsinovariectomizedSpargue—Dawleyrats．Methods：70female44一week-oldSpargue-Dawleyratswererandomlydividedintofourgroups：10ratsinbasel

2、inegroup(BS)，20ratsinsham—operated(SHAM)，20ratsinovariectomizedgroup(OVX)and20ratsinovariectomized+calcitoningroup(OVX+C)，Thebaselinegroupwerekilledatthebeginningoftheexperiment．Atthe4rd，12thweekafteroperationtheratswerekilledrespectively．The4thvertebraewereusedforfatiguedamagete

3、stbyPLD5010bonefatigueexperimentdevice．Theparametersoflinearmicrocrackweremeasuredandtherightfemurwereusedforthree-pointbendingtests．Results：Microdamagecouldbeviewedineverysample，includingmicrocrack，fewcross—hatchingmicrodamage，diffusedamageandmicrofracture．microcrackwasthemostus

4、ualmicrodamagetype．At4thweek,Significantdifferenceofmicrocrackparameters(Meanmicrocracklength，Microcracksurfacedensity，Microcrackdensity)ofvertebraewasobservedbetweenOVXgroupandSHAMgroup(P<0．05)，OVXgroupandOVX+Cgroup(P<0．05)，alsobetweenOVX+CandSHAMgroup(P

5、ignificantdifferenceofmicrocrackparametersofvertebraewasobservedbetweenOVXgroupandSHAMgroup(P<0．05)，alsobetweenOVXgroupandOVX+Cgroup(P0．05)．Thereisnosignificantdifferenceofbiomechanicsparametersofthefightfemurineachgroupat4thand12thweek(P>0

6、．05)．Conclusion：CalcitonincallimprovebonemicrostructureofvertebraeandthereisnosignificanteffectonbiomechanicsofthefemurinovariectomizedSpargue-Dawleyrats．ThemicrocrackparametersCanbeconsideredalternativeparametersintheevaluationofbonemicrostructurequality．keywords：osteoporosis；ca

7、lcitonin；microdamage；biomechanicsClassification：R589．1V万方数据目录学位论文原创性声明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯I中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯II英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．IV目录⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VI中英文名词及缩略语表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯VII第一章前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．1第二章材料

8、与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯32．1主要材料及设备⋯