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1、海南医学2013年7月第24卷第13期doi:10.3969/j.issn.1003-6350.2013.13.0786·论著·传统与新型抗癫痫药物治疗新诊断癫痫患者的一年保留率比较郭丽冰，吴志刚，李济田，卢惠娴，杜韵华，吴伟博(佛山市第三人民医院神经内科，广东佛山528000)【摘要】目的比较一线的传统与新型的抗癫痫药物治疗新诊断癫痫患者的保留率，为癫痫患者维持治疗的药物选择提供依据。方法通过门诊随诊对269例新诊断的癫痫患者按发作类型随机给予苯妥英钠、丙戊酸钠、卡马西平、拉莫三嗪、托吡酯、奥
2、卡西平单药治疗，比较它们的一年保留率，并详细记录停药原因。结果一年保留率统计，传统的抗癫痫药物分别为苯妥英钠63.5%、丙戊酸钠67.3%、卡马西平68.6%，新型的抗癫痫药物分别为拉莫三嗪88.5%、托吡酯74.5%、奥卡西平75%，传统与新型抗癫痫药物的一年保留率比较差异均有统计学意义(P＜0.05)。在停药的原因方面，传统抗癫痫药物(52.5%)比新型抗癫痫药物(26.7%)更容易因为药物副作用而停药，两者比较差异也有统计学意义(P＜0.05)。结论新型抗癫痫药物治疗新诊断癫痫患者的一年保
3、留率较传统的抗癫痫药物高，提示对于新诊断癫痫患者应优先选择新型的抗癫痫药物作为单药治疗。【关键词】保留率；癫痫；传统抗癫痫药物；新型抗癫痫药物【中图分类号】R742.1【文献标识码】A【文章编号】1003—6350(2013)13—1895—03Comparisonofoneyearretentionratebetweentraditionalandnewantiepilepticdrugsinpatientswithnewlydiagnosedepilepsy.GUOLi-bing,WUZhi
4、-gang,LIJi-tian,LUHui-xian,DUYun-hua,WUWei-bo.DepartmentofNeurology,theThirdPeople'sHospitalofFoshanCity,Foshan528000,Guangdong,CHINA【Abstract】ObjectiveTocomparetheretentionrateoftraditionalantiepilepticdrugsandnewantiepilepticdrugsinthetreatmentofne
5、wlydiagnosedepilepticpatients,andtoprovidebasisfordrugselectionofmaintenancetreatment.MethodsAtotalof269epilepticpatientsnewlydiagnosedintheOutpatientDepartmentwererandomlygivensingledrugtherapyaccordingtoseizuretypes,includingtraditionalantiepilepti
6、cdrugs(Phenytoin,SodiumVal-proate,Carbamazepine)andnewantiepilepticdrugs(Lamotrigine,OxcarbazepineandTopiramate).Theretentionrateswerecomparedafteroneyear,andthereasonsforwithdrawalindetailwererecorded.ResultsTheoneyearre-tentionratesofnewantiepilept
7、icdrugs[Lamotrigine(88.5%),Oxcarbazepine(75%),Topiramate(74.5%)]weresignif-icantlydifferentfromthoseoftraditionalantiepilepticdrugs[Phenytoin(63.5%),SodiumValproate(67.3%),Carbam-azepine(68.6%)].Patientstreatedwithtraditionalantiepilepticdrugs(52.5%)
8、weremuchmorelikelytowithdrawthanthosetreatedwithnewantiepilepticdrugs(26.7%)becauseofsideeffects.ConclusionTheretentionrateofnewan-tiepilepticdrugsissignificantlyhigherthanthetraditionalantiepilepticdrugsinnewlydiagnosedepilepticpatients.Toselectnewa
