Using simple donors to drive the equilibria of glycosyltransferase-catalyzed.pdf

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1、Usingsimpledonorstodrivetheequilibriaofglycosyltransferase-catalyzedreactions:NatureChemicalBiology:NaturePublishingGroupnature.comPublicationsA-ZindexBrowsebysubjectMyaccountSubmitmanuscriptRegisterSubscribeFulltextaccessprovidedtoNanjinguniversitybylibrarySearchGoAdv

2、ancedsearchnature.comjournalhomeadvanceonlinepublicationarticlefulltextpreviousarticlenextarticleNATURECHEMICALBIOLOGY

3、ARTICLEJournalhomeSubscribeUsingsimpledonorstodrivetheCurrentissueE-alertsignupForauthorsRSSfeedequilibriaofglycosyltransferase-catalyzedreactionsRich

4、ardWGantt,PaulinePeltier-Pain,WilliamJCournoyer&JonSThorsonAffiliationsContributionsCorrespondingauthorNatureChemicalBiology(2011)doi:10.1038/nchembio.638Received18February2011Accepted24June2011PublishedonlineInsidethisarticle21August2011CompoundsHighlightingtoolCompou

5、ndsGenesandProteinsPrevAbstractAbstractIntroductionResultsDiscussionMethodsAdditionalinformationReferencesAcknowledgmentsAuthorinformationSupplementaryinformation1.Wereportthatsimpleglycosidedonorscanemaildrasticallyshifttheequilibriaofglycosyltransferase-catalyzedreac

6、tions,downloadpdfCompound1transformingNDP-sugarformationfromandownloadcitationendothermictoanexothermicprocess.Toorderreprintsdemonstratetheutilityofthisthermodynamicrightsandpermissionsadaptability,wehighlighttheglycosyltransferase-catalyzedsynthesisof22share/bookmark

7、sugarnucleotidesfromsimplearomaticsugarconnoteaciteulikedonors,aswellasthecorrespondinginsitu2.http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.638.html#/supplementary-information[2011-9-414:55:02]Usingsimpledonorstodrivetheequilibriaofglycosyltransfe

8、rase-catalyzedreactions:NatureChemicalBiology:NaturePublishingGroupformationofsugarnucleotidesasadrivingfacebooktwitterforceinthecontextofglycosyltransferase-catalyzedreactionsforsmall-deliciousdiggmoleculeglycodiversification.Thesesimplearomaticdonorsalsoenabledagener

9、alcolorimetricassayforglycosyltransfer,applicabletodrugdiscovery,Compound2proteinengineeringandotherfundamentalsugarn