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ID:34148970
大小:2.31 MB
页数:40页
时间:2019-03-03
《不同脑血管病患者脑微出血危险因素-分析及阿托伐他汀钙对脑微出血的影响》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、万方数据中文摘要CMBs(+)组中,年龄、高血压、脑梗死、脑出血、腔隙性脑梗死比较CMBs(.)差异有统计学意义(P2、脂胆固醇水平高低分为3组,每组给不同剂量他汀类药物;强化降脂组40m∥d+标准治疗、标准降脂组20m/dg+标准治疗和非降脂组0mg/d+标准治疗;3个月后复查SWI记录脑微出血部位、数量,并抽血复查总胆固醇、低密度脂蛋白水平。对比用药前后脑微出血变化有无统计学意义。结果:1强化组或标准组降脂治疗3个月后,总胆固醇水平、低密度脂蛋白有下降(P3、,1例增加4个(0rag组);脑微出血灶前后数量变化无显著差异(P>0.05)。结论:1不同脑血管病CMBs检出率不同:合并脑出血最高、再次腔隙性脑梗死、再次急性脑梗死,TIA最低。2脑微出血好发部位、数量:皮层.皮层下比例最多,基底节.丘脑次之,再次小脑,脑干最小;轻度数量程度(1-2个)患者比例最高。3脑梗死、腔隙性脑梗死、脑出血、与CMBs呈正相关,为其高危因素。4总胆固醇血症(TC)、高低密度脂蛋白血症(LDL—C1、高同型半胱氨酸血症(HCⅥ与为CMBs呈正相关,为其高危因素。5尿酸(UA)、纤维蛋白原(FIB4、)与CMBs无明显相关。万方数据中文摘要6阿托伐他汀治疗可降低胆固醇水平、低密度脂蛋白至正常值水平。7短期应用阿托伐他汀降脂治疗不会增加脑微出血的风险。关键词:脑微出血,危险因素,磁敏感加权成像,阿托伐他汀,降脂万方数据英文摘要DifferentmicrocerebrovasculardiseasecerebralhemorrhageriskfactoranalysisandmicroatorvastatinoncerebralhemorrhageABSTRACTWiththenuclearmagneticresonan5、ce(r,wm)andGREsequenceSWIsequencetechnologyiswidelyusedinclinical,braincapillaryhemorrhagewasmuchhigher,withthe1994Schaxfetc,putsforwardtheconceptofhemorrhagelacunarFazekasby1999throughpathologyconfirmedtheexistenceofmicrocerebralhemorrhage,cerebralmicrohemorrhag6、e(cerebralmierobleed,CMBs)graduallybeneurologistscholarshaveextensiveandin—depthresearch.Microbrainhemorrhage(cerebralmierobleed,CMBs)aresmallvascularlesions,tinybloodvesselsinthebrainburstbleeds,causeofhemosiderin,hemosiderindepositionofasubclinicallesions[1]the7、end—stageoftinybloodvessels.In2010inthenewcerebrovasculardiseaseclassificationwasofficiallyclassifiedasasubtypeofsmallvasculardiseaseofthebrain.Offenbacher【2]2forthefirsttimesuchasdescribedintheGREsequence2—5mmindiameterovoidsignaltoreducearea,thesurroundingedema8、.Inadditionalsoneedtoruleoutsmallintracranialvascularclearance。hemosiderindepositionbetweenthepiamaterandsubcorticalcalcifications.SeveralstudiesshowthatCMBsti
2、脂胆固醇水平高低分为3组,每组给不同剂量他汀类药物;强化降脂组40m∥d+标准治疗、标准降脂组20m/dg+标准治疗和非降脂组0mg/d+标准治疗;3个月后复查SWI记录脑微出血部位、数量,并抽血复查总胆固醇、低密度脂蛋白水平。对比用药前后脑微出血变化有无统计学意义。结果:1强化组或标准组降脂治疗3个月后,总胆固醇水平、低密度脂蛋白有下降(P3、,1例增加4个(0rag组);脑微出血灶前后数量变化无显著差异(P>0.05)。结论:1不同脑血管病CMBs检出率不同:合并脑出血最高、再次腔隙性脑梗死、再次急性脑梗死,TIA最低。2脑微出血好发部位、数量:皮层.皮层下比例最多,基底节.丘脑次之,再次小脑,脑干最小;轻度数量程度(1-2个)患者比例最高。3脑梗死、腔隙性脑梗死、脑出血、与CMBs呈正相关,为其高危因素。4总胆固醇血症(TC)、高低密度脂蛋白血症(LDL—C1、高同型半胱氨酸血症(HCⅥ与为CMBs呈正相关,为其高危因素。5尿酸(UA)、纤维蛋白原(FIB4、)与CMBs无明显相关。万方数据中文摘要6阿托伐他汀治疗可降低胆固醇水平、低密度脂蛋白至正常值水平。7短期应用阿托伐他汀降脂治疗不会增加脑微出血的风险。关键词:脑微出血,危险因素,磁敏感加权成像,阿托伐他汀,降脂万方数据英文摘要DifferentmicrocerebrovasculardiseasecerebralhemorrhageriskfactoranalysisandmicroatorvastatinoncerebralhemorrhageABSTRACTWiththenuclearmagneticresonan5、ce(r,wm)andGREsequenceSWIsequencetechnologyiswidelyusedinclinical,braincapillaryhemorrhagewasmuchhigher,withthe1994Schaxfetc,putsforwardtheconceptofhemorrhagelacunarFazekasby1999throughpathologyconfirmedtheexistenceofmicrocerebralhemorrhage,cerebralmicrohemorrhag6、e(cerebralmierobleed,CMBs)graduallybeneurologistscholarshaveextensiveandin—depthresearch.Microbrainhemorrhage(cerebralmierobleed,CMBs)aresmallvascularlesions,tinybloodvesselsinthebrainburstbleeds,causeofhemosiderin,hemosiderindepositionofasubclinicallesions[1]the7、end—stageoftinybloodvessels.In2010inthenewcerebrovasculardiseaseclassificationwasofficiallyclassifiedasasubtypeofsmallvasculardiseaseofthebrain.Offenbacher【2]2forthefirsttimesuchasdescribedintheGREsequence2—5mmindiameterovoidsignaltoreducearea,thesurroundingedema8、.Inadditionalsoneedtoruleoutsmallintracranialvascularclearance。hemosiderindepositionbetweenthepiamaterandsubcorticalcalcifications.SeveralstudiesshowthatCMBsti
3、,1例增加4个(0rag组);脑微出血灶前后数量变化无显著差异(P>0.05)。结论:1不同脑血管病CMBs检出率不同:合并脑出血最高、再次腔隙性脑梗死、再次急性脑梗死,TIA最低。2脑微出血好发部位、数量:皮层.皮层下比例最多,基底节.丘脑次之,再次小脑,脑干最小;轻度数量程度(1-2个)患者比例最高。3脑梗死、腔隙性脑梗死、脑出血、与CMBs呈正相关,为其高危因素。4总胆固醇血症(TC)、高低密度脂蛋白血症(LDL—C1、高同型半胱氨酸血症(HCⅥ与为CMBs呈正相关,为其高危因素。5尿酸(UA)、纤维蛋白原(FIB
4、)与CMBs无明显相关。万方数据中文摘要6阿托伐他汀治疗可降低胆固醇水平、低密度脂蛋白至正常值水平。7短期应用阿托伐他汀降脂治疗不会增加脑微出血的风险。关键词:脑微出血,危险因素,磁敏感加权成像,阿托伐他汀,降脂万方数据英文摘要DifferentmicrocerebrovasculardiseasecerebralhemorrhageriskfactoranalysisandmicroatorvastatinoncerebralhemorrhageABSTRACTWiththenuclearmagneticresonan
5、ce(r,wm)andGREsequenceSWIsequencetechnologyiswidelyusedinclinical,braincapillaryhemorrhagewasmuchhigher,withthe1994Schaxfetc,putsforwardtheconceptofhemorrhagelacunarFazekasby1999throughpathologyconfirmedtheexistenceofmicrocerebralhemorrhage,cerebralmicrohemorrhag
6、e(cerebralmierobleed,CMBs)graduallybeneurologistscholarshaveextensiveandin—depthresearch.Microbrainhemorrhage(cerebralmierobleed,CMBs)aresmallvascularlesions,tinybloodvesselsinthebrainburstbleeds,causeofhemosiderin,hemosiderindepositionofasubclinicallesions[1]the
7、end—stageoftinybloodvessels.In2010inthenewcerebrovasculardiseaseclassificationwasofficiallyclassifiedasasubtypeofsmallvasculardiseaseofthebrain.Offenbacher【2]2forthefirsttimesuchasdescribedintheGREsequence2—5mmindiameterovoidsignaltoreducearea,thesurroundingedema
8、.Inadditionalsoneedtoruleoutsmallintracranialvascularclearance。hemosiderindepositionbetweenthepiamaterandsubcorticalcalcifications.SeveralstudiesshowthatCMBsti
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