化疗治愈肿瘤动物模型的建立及小剂量ctx抗肿瘤作用机制研究

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1、照组荷瘤小鼠1．20±O．72Eu／ml(p

2、。小剂量CTX用药后72h内，荷瘤小鼠肿瘤组织内MDA含量的逐渐下降，提示肿瘤细胞的死亡与氧化应激损伤无关。小剂量CTX用药后6h，荷瘤小鼠体内未出现内毒素血症，CTX用药后72h内血浆NO含量的持续增高与可能CTX用药后血浆PAF水平的升高和肿瘤血管内皮细胞的损伤有关。关键词：环磷酰胺(cyclophosphamide，CTX)膀胱癌T739小鼠肿瘤治愈血小板血小板激活因子Establishmentofananimalmodeloftumor．．bearingmicecuredbyalowdoseofchemotherapyanditspossiblemechanisms

3、PhDCandidate：MolinLiSuperviSOr：Prof．YuJieJiaMajorSubject：PathologyandPathophy8iologyAbstraetobjective：Withthegreatchangesinhumanlifestyleandenvironment．themalignanttumorhasbecomeoneofthemostcommondiseasesendangeringhumanhealthinmodernsociety．Accordingtostatistics，about7millionpeoplearediag

4、nosedandnearly5millionpeopledieofcancerworldwideeachyear·Inrecentyearstherehasbeenanincreasingtrendintheincidenceandmortalityofmalignanttumorsinchina．BecausethecauseofmalignanttumorsiSnotcompletelyclear，atthepresenttimecombinedtreatmentmethodsincludingsurgery，chemotherapy，radiotherapy，trea

5、tmentwithbiologicalagentsandSOonhadbeenadoptedinclinic．andsystematictreatmentwithcytotoxicdrugshasbeenthebasisofmosteffectivetreatmentsforpatientswithdisseminatedcancers．Itisthoughtthatcytotoxicdrugsinhibitorkilltumorcellsinadosedependentmanner．Itwasreportedthatahighdoseofchemotherapycould

6、curegestationaltrophoblastictumorinclinic，butfiveyearssurvivalrateofmostpatientswithmalignanttumorswasnotelevatedsignificantlywithahighdosechemotherapyscheme．Itwasfoundthatahighdoseofchemotherapycouldincreasenotonlytheshort—termeffectsontumor，butalsothedose．dependentsideeffects．Anditwasnot

7、favorabletoimprovingthepatients’qualityoflifeandelevatingthelong·termtherapeuticefficacy．Withthemedicalmodelchanges，itwasrealizedlivingqualityandprolongedsurvivaltimeareofdecisivesignificanceforpatientswithmalignanttumors，andtumor。shrinkageisnottheprimarygoalo