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ID:34061348
大小:8.88 MB
页数:68页
时间:2019-03-03
《化疗治愈肿瘤动物模型的建立及小剂量ctx抗肿瘤作用机制研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、照组荷瘤小鼠1.20±O.72Eu/ml(p2、。小剂量CTX用药后72h内,荷瘤小鼠肿瘤组织内MDA含量的逐渐下降,提示肿瘤细胞的死亡与氧化应激损伤无关。小剂量CTX用药后6h,荷瘤小鼠体内未出现内毒素血症,CTX用药后72h内血浆NO含量的持续增高与可能CTX用药后血浆PAF水平的升高和肿瘤血管内皮细胞的损伤有关。关键词:环磷酰胺(cyclophosphamide,CTX)膀胱癌T739小鼠肿瘤治愈血小板血小板激活因子Establishmentofananimalmodeloftumor..bearingmicecuredbyalowdoseofchemotherapyanditspossiblemechanisms3、PhDCandidate:MolinLiSuperviSOr:Prof.YuJieJiaMajorSubject:PathologyandPathophy8iologyAbstraetobjective:Withthegreatchangesinhumanlifestyleandenvironment.themalignanttumorhasbecomeoneofthemostcommondiseasesendangeringhumanhealthinmodernsociety.Accordingtostatistics,about7millionpeoplearediag4、nosedandnearly5millionpeopledieofcancerworldwideeachyear·Inrecentyearstherehasbeenanincreasingtrendintheincidenceandmortalityofmalignanttumorsinchina.BecausethecauseofmalignanttumorsiSnotcompletelyclear,atthepresenttimecombinedtreatmentmethodsincludingsurgery,chemotherapy,radiotherapy,trea5、tmentwithbiologicalagentsandSOonhadbeenadoptedinclinic.andsystematictreatmentwithcytotoxicdrugshasbeenthebasisofmosteffectivetreatmentsforpatientswithdisseminatedcancers.Itisthoughtthatcytotoxicdrugsinhibitorkilltumorcellsinadosedependentmanner.Itwasreportedthatahighdoseofchemotherapycould6、curegestationaltrophoblastictumorinclinic,butfiveyearssurvivalrateofmostpatientswithmalignanttumorswasnotelevatedsignificantlywithahighdosechemotherapyscheme.Itwasfoundthatahighdoseofchemotherapycouldincreasenotonlytheshort—termeffectsontumor,butalsothedose.dependentsideeffects.Anditwasnot7、favorabletoimprovingthepatients’qualityoflifeandelevatingthelong·termtherapeuticefficacy.Withthemedicalmodelchanges,itwasrealizedlivingqualityandprolongedsurvivaltimeareofdecisivesignificanceforpatientswithmalignanttumors,andtumor。shrinkageisnottheprimarygoalo
2、。小剂量CTX用药后72h内,荷瘤小鼠肿瘤组织内MDA含量的逐渐下降,提示肿瘤细胞的死亡与氧化应激损伤无关。小剂量CTX用药后6h,荷瘤小鼠体内未出现内毒素血症,CTX用药后72h内血浆NO含量的持续增高与可能CTX用药后血浆PAF水平的升高和肿瘤血管内皮细胞的损伤有关。关键词:环磷酰胺(cyclophosphamide,CTX)膀胱癌T739小鼠肿瘤治愈血小板血小板激活因子Establishmentofananimalmodeloftumor..bearingmicecuredbyalowdoseofchemotherapyanditspossiblemechanisms
3、PhDCandidate:MolinLiSuperviSOr:Prof.YuJieJiaMajorSubject:PathologyandPathophy8iologyAbstraetobjective:Withthegreatchangesinhumanlifestyleandenvironment.themalignanttumorhasbecomeoneofthemostcommondiseasesendangeringhumanhealthinmodernsociety.Accordingtostatistics,about7millionpeoplearediag
4、nosedandnearly5millionpeopledieofcancerworldwideeachyear·Inrecentyearstherehasbeenanincreasingtrendintheincidenceandmortalityofmalignanttumorsinchina.BecausethecauseofmalignanttumorsiSnotcompletelyclear,atthepresenttimecombinedtreatmentmethodsincludingsurgery,chemotherapy,radiotherapy,trea
5、tmentwithbiologicalagentsandSOonhadbeenadoptedinclinic.andsystematictreatmentwithcytotoxicdrugshasbeenthebasisofmosteffectivetreatmentsforpatientswithdisseminatedcancers.Itisthoughtthatcytotoxicdrugsinhibitorkilltumorcellsinadosedependentmanner.Itwasreportedthatahighdoseofchemotherapycould
6、curegestationaltrophoblastictumorinclinic,butfiveyearssurvivalrateofmostpatientswithmalignanttumorswasnotelevatedsignificantlywithahighdosechemotherapyscheme.Itwasfoundthatahighdoseofchemotherapycouldincreasenotonlytheshort—termeffectsontumor,butalsothedose.dependentsideeffects.Anditwasnot
7、favorabletoimprovingthepatients’qualityoflifeandelevatingthelong·termtherapeuticefficacy.Withthemedicalmodelchanges,itwasrealizedlivingqualityandprolongedsurvivaltimeareofdecisivesignificanceforpatientswithmalignanttumors,andtumor。shrinkageisnottheprimarygoalo
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