寻常型银屑病皮损中t-cadherin与p-cadherin的表达及相关性研究

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1、statisticdifferenceweresignificantbetweenthem(P<0．05)andverysignificant(P

2、stP<0．01)；②ThepositiverateofP．cadherinwas78．95％inPVplaquetissue，while15．38％innormalepidermistissue．ThepositiveratewassignificantdifferencebetweeninPVplaquetissueandinnormalepidermistissue(chi—squaretestP<0．01)；③TheexpressionlevelofT-cadherinwascorrelatedwithfamilyhistoryofpatient(

3、rank-sumtestP

4、instablephaseandinparacmasis，whilenosignificantassociationwiththesexandageofpatient，alsopruritusandfamilyhistoryofpatient；⑤InPVplaquetissue，T—cadherinwasnegativelycorrelatedwithexpressionofP·-cadherinsignificantly(Kendallstau·-bcorrelationanalysistau．b=O．461，P<0．01)．Conclusion：OTh

5、eexpressionofT—cadherinweresignificantlydifferentbetweeninPVplaquetissueandinnormalepidermistissue，whichpromptoverexpressionoftowmayplayanimportantroleinpathogenicmechanismofPV；②Theexpressionof6P-cadherinweresignificantlydifferentbetweeninPVplaquetissueandinnormalepidermistissue，w

6、hichsuggestedabnormalexpressionofp-cadherinisconcernedwithitsexcessivekeratinocyteproliferation；@TheexpressionlevelofT—cadherinwasnotcorrelatedwiththesexandageofpatient，alsopruritusandclinicalstage。butTheexpressionlevelofT-cadherinwascorrelatedwithfamilyhistoryofpatient；whichwashi

7、gherwithfamilyhistorythanwithoutfamilyhistory(P

8、alstage；wichwashigherinactivestag