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1、AbstractObjective:ToinvestigatethecatgutimplantationatAcupointonepilepticratseizurebehaviorandtheinfluenceofNeuron-specificenolase(NSE)inratbraintissues.Method:65ratswererandomlydividedintotheacupointcatgutembeddinggroup,sodiumvalproategroup,acupuncturegroup,modelgroupandblankgro
2、up,afterpretreatmentthreedaysandpenicillinintraperitonealinjectionmoldingisodoseandsameproportion,recordlevelofseizuresandlatencyoftheratsineachgroupanddetermineNSElevelinratbraintissuesbyElisaon0h、24h、48haftergrandmalepilepsy.Results:①Inthemodelgroup15rats,ofwhich13IV~V-classgra
3、ndmal,seizuresrateis92.9%,onedeathsaftertheClassVseizures.OneofsodiumvalproategrouphasadeathafterClassVseizures.Theseizuresrateofacupointcatgutembeddinggroup,sodiumvalproategroup,acupuncturegroupIV~V-classgrandmalfollowedby33.3%、33.3%、40.0%,Theacupointcatgutembeddinggroup,sodiumv
4、alproategroup,acupuncturegroupcomparedwithmodelgroup,canreduceobviouslythedegreeofseizures(P<0.05);ThesodiumvalproategroupIV~Vlevellessthanacupointcatgutembeddinggroupandacupuncturegroup(P=0.003<0.01),butthreegroupswasnotstatisticallysignificant(P>0.05);②acupointcatgutembeddinggr
5、oup,sodiumvalproategroup,acupuncturegroupcomparedwithmodelgroup,canobviouslyextendthelatencyperiod,thedifferencewasstatisticallysignificant(P<0.01),andthe3grouptoembeddinggroupwasmostpronouncedin(18.3+2.7),butthedifferencebetweenthe3groupswasnotstatisticallysignificant(P>0.05);③A
6、cupointcatgutembeddinggroup,sodiumvalproategroup,acupuncturegroupcompared,modelgrouparehigherobviouslythantheblankgroup(P<0.01).NSElevelofacupointcatgutembeddinggroup,sodiumvalproategroup,acupuncturegroupcomparedwithmodelgroupwassignificantlylower,thedifferencewasstatisticallysig
7、nificant(p<0.01);NSElevelofacupointcatgutembeddinggroup,sodiumvalproategroup,acupuncturegroupwerenosignificantdifferences(P>0.05);④Aftertheseizures0h,themodelofNSElevelhasahigh,the24hinthepeakofthethreetimeperiods;Sodiumvalproategroup,acupuncturegroup,acupointcatgutembeddinggroup
8、ofNSEisinconsistentinthedistributionofea
