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ID:33924555
大小:1.03 MB
页数:48页
时间:2019-03-02
《夹脊电针治疗腰椎间盘突出症的临床观察与其对兔退变腰椎间盘decorin蛋白表达的影响》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、计学意义(P<0.05);治疗组总有效率为89.66%,对照组总有效率为82.76%,两组临床总有效率经过统计学分析,差异有统计学意义(P<0.05)2实验研究结果:正常组、假手术组各时间点decorin含量相差很小,差异无统计学意义(均P>0.05);模型组第28天、第56天及电针组的第28天decorin表达较正常组第28天明显下降,差异均有统计学意义(均P<0.05);模型组第28天、第56天及电针组的第28天decorin表达较假手术组第28天明显下降,差异均有统计学意义(均P<0.05);模型组第
2、56天decorin含量较本组第28天进一步下降,差异有统计学意义(P<0.05),而电针组第56天decorin含量与本组第28天时及模型组第56天时相比均呈上升趋势,差异均具有统计学意义(均P<0.05)。结论1夹脊电针组和电针常规穴都能有效改善LDH患者的不适症状,降低腰腿疼痛对日常生活和工作的影响。但夹脊电针方法效果更好,可以作为LDH的针刺优选方案进行推广。2轴向加压是诱导兔腰椎间盘退变继而影响细胞外基质变化的重要因素之一;decorin参与了腰椎间盘退变的进程,并随着腰椎间盘的退变的发生而表达下
3、调;夹脊电针治疗可以使兔退变椎间盘组织中decorin的蛋白表达上调,通过纠正基质降解与合成代谢之间的失衡来达到延缓椎间盘退变的作用。关键词:夹脊穴;电针;腰椎间盘突出症;腰椎间盘退变;核心蛋白聚糖IIClinicalObservationofEAatJiajiPointsinTreatingLumbarDiscHermiationandTheEffectofEAontheProteinExpressionofDeco-rininaRabbitwithLumbarDiscDegenerationAuthor
4、:BoyiWangSupervisor:ProfessorGuofuHuangABSTRACTObjectiveThissubjectwasdividedintoclinicalobservationandexperimentalresearchtwoparts.Intheclinicalpart,wecomparedthecurativeeffectsofEAatJiajipointsandBeishupointsintreatingLumbarDiscHerniation(LDH).Weaimedatc
5、hoosingabettertreatmentofacupunctureintreatingLDH.Intheexperimentalpart,weconstructedtheanimalmodelsoflumbardiscdegenerationandobservedtheinfluenceofdecorinexpressioninthetissuesoftherabbitlumbardiscdegenerationbythetreatmentofEAatJiajipoints.Throughthisre
6、searchwecouldexploretheactionmechanismoflumbardiscdegenerationctreatedbytheEAatJiajipointsfurther.Method1Clinicalobservation:Sixtypatientschosenbyadoptionstandardswererandomlydividedintotreatmentgroup(EAatJiajipointsgroup)andcontrolgroup(EAatRegularpointsg
7、roup),eachgrouphas30cases.Ac-tuallytherewereonly29patientsineachgroupfinallybecauseof1patientineachgroupwaseliminateduingthestudy.Eachgroupwasgivenelectroacupuncturetherapyonceaday,6timescontinuousasacourseoftreatment,beforethenextcourseoftreatmenthasoneda
8、yinterval.Thetreatmentweretwocoursestotal.Oswestrydisabilityindexquestionnairewasselectedtoevaluatethetherapeuticeffectsoftwogroupsbeforeandaftertreatment.ModifiedMacnabcurativeeffectevaluationstandardwasIIIu
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