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1、Bacteria-inducednaturalproductformationinthefungusAspergillusnidulansrequiresSaga/Ada-mediatedhistoneacetylationa,bc,deafHans-WilhelmNützmann,YazmidReyes-Dominguez,KirstinScherlach,VolkerSchroeckh,FabianHorn,c,deb,e,1c,d,1a,b,1AgnieszkaGacek,JuliaSchümann,ChristianHe
2、rtweck,JosephStrauss,andAxelA.BrakhageaefDepartmentsofMolecularandAppliedMicrobiologyandBiomolecularChemistry,andResearchGroup:SystemsBiology/Bioinformatics,LeibnizInstitutecforNaturalProductResearchandInfectionBiology–HansKnöllInstitute,07745Jena,Germany;FungalGenet
3、icsandGenomicsUnit,DepartmentofdAppliedGeneticsandCellBiology,UniversityofNaturalResourcesandLifeSciencesandAustrianInstituteofTechnologyGmbH,HealthandbEnvironmentDepartment,A-3430Tulln,Austria;andFriedrichSchillerUniversityJena,D-07745Jena,GermanyEditedbyJayC.Dunlap
4、,DartmouthMedicalSchool,Hanover,NH,andapprovedJuly12,2011(receivedforreviewMarch3,2011)Sequenceanalysesoffungalgenomeshaverevealedthatthereservoir,however,istheobservationthatmostofthesegenepotentialoffungitoproducesecondarymetabolitesisgreatlyclustersaresilentunders
5、tandardlaboratoryconditions(6–8).Tounderestimated.Infact,mostgeneclusterscodingforthebiosyn-addressthisproblem,methodswereestablishedtoactivatesilentthesisofantibiotics,toxins,orpigmentsaresilentunderstandardgeneclustersbygeneticengineering(6,7,9).Themostchallengingl
6、aboratoryconditions.Hence,itisoneofthemajorchallengesinquestion,however,istheidentificationofthetruefunctionofmicrobiologytouncoverthemechanismsrequiredforpathwaythesecompoundsinthehabitat.Becausethesefunctionsareactivation.Recently,wediscoveredthatintimatephysicalint
7、erac-largelyunknown,itisnotpossibletodevelopstrategiesonara-tionoftheimportantmodelfungusAspergillusnidulanswiththetionalebasisfortheactivationoftheirbiosyntheses.Itishighlysoil-dwellingbacteriumStreptomycesrapamycinicusspecificallyac-likelythatmanyofthesecompoundsare
8、producedaschemicaltivatedsilentfungalsecondarymetabolismgenes,resultinginthesignalmoleculesorfordefendingthehabitat(10,11).Inthispr
