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1、AgeingResearchReviews10(2011)1–15ContentslistsavailableatScienceDirectAgeingResearchReviewsjournalhomepage:www.elsevier.com/locate/arrReviewEffectofagingoncellularmechanotransductiona,b,db,ca,b,da,ea,b,c,d,*MiaozongWu,JacquelineFannin,KevinM.Rice,BinWang,EricR.Blou
2、ghaCellDifferentiationandDevelopmentCenter,MarshallUniversity,Huntington,WV,UnitedStatesbDepartmentofBiologicalSciences,MarshallUniversity,Huntington,WV,UnitedStatescDepartmentofPharmacology,PhysiologyandToxicology,MarshallUniversity,JoanC.EdwardsSchoolofMedicine,H
3、untington,WV,UnitedStatesdDepartmentofExerciseScience,SportandRecreation,CollegeofEducationandHumanServices,MarshallUniversity,Huntington,WV,UnitedStateseDepartmentofChemistry,MarshallUniversity,Huntington,WV,UnitedStatesARTICLEINFOABSTRACTArticlehistory:Agingisbec
4、omingacriticalheathcareissueandaburgeoningeconomicburdenonsociety.Received14July2009Mechanotransductionistheabilityofthecelltosense,process,andrespondtomechanicalstimuliandisReceivedinrevisedform11November2009animportantregulatorofphysiologicfunctionthathasbeenfoun
5、dtoplayaroleinregulatinggeneAccepted16November2009expression,proteinsynthesis,celldifferentiation,tissuegrowth,andmostrecently,thepathophysiologyofdisease.Herewewillreviewsomeoftherecentfindingsofthisfieldandattempt,wherepossible,toKeywords:presentchangesinmechanotra
6、nsductionthatareassociatedwiththeagingprocessinseveralselectedAgingphysiologicalsystems,includingmusculoskeletal,cardiovascular,neuronal,respiratorysystemsandMechanotransductionskin.MusculoskeletalPublishedbyElsevierIrelandLtd.CardiovascularNeuronalRespiratorysyste
7、mSkin1.Introductionologyofdisease(Ingber,2003a).RecentdatastronglysupportsthisnotionasitisbecomingrecognizedthatmanyaspectsofTheagedpopulationnowcomprisesthefastestgrowingsarcopenia,cardiovascularandrespiratorydiseasemayberelatedsegmentofpeoplelivingintheUnitedStat
8、es.Livinglongeristoalterationincellularmechanotransduction(Bloughandassociatedwithhighermorbidity.Indeed,healthcarespendingperLinderman,2000;Rice
