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1、提要目的:观察健脾化痰祛瘀法治疗冠心病稳定型心绞痛气虚血瘀、痰浊内阻证的疗效并探讨其机理。方法:临床研究选择冠心病稳定型劳累性心绞痛气虚血瘀、痰浊内阻证患者60例,随机分为试验组和对照组各30例,试验组给予西药基础治疗加用健脾化痰祛瘀汤治疗,对照组给予西药基础治疗,观察治疗前后临床疗效和实验室检查变化。结果:经治疗4周后,心绞痛疗效,试验组显效率为33.33%、总有效率为76.67%,对照组显效率为16.67%、总有效率为50%;中医症候疗效,试验组显效率为33.33%、总有效率为90%,对照组显效率为16.67%、
2、总有效率为60%;心电图疗效,试验组显效率为30%、总有效率为73.33%,对照组显效率为16.67%、总有效率为43.33%。两组比较有显著性差异(P<0.05)。与对照组相比,试验组治疗后血脂、血液流变学均有较大改善(P<0.01、P<0.01)。结论:本研究结果显示健脾化痰祛瘀汤对稳定型心绞痛气虚血瘀、痰浊内阻证有显著的临床疗效,能明显缓解心绞痛,改善心肌缺血,缓解胸痛、胸闷等主要症状,能调节血脂,改善血液流变学,提高临床疗效和中医症候疗效,可推广于临床。治疗后无明显不良反应。关键词稳定型心绞痛;气虚血瘀、痰浊
3、内阻证;健脾化痰祛瘀汤;临床研究ClinicalStudyontheMethodofTonifyingtheSpleenandDissipatingPhlegmandBloodStasisinTreatingAnginaofCoronaryHeartDiseaseSpeciality:HeartDisease,TraditionalChineseInternalMedicineAuthor:LiuJianyingTutor:ProfessorZhangShiliangAbstractObjective:Toobser
4、vetheclinicalcurativeeffectoftreatingsyndromeofQi-astheniaandPhlegm-StasisofstableanginacausedbycoronaryheartdiseasethroughapplyingtheJianpihuatanquyudecoctionandToexploreitsmechanism.Methods:60patientswithstableanginaofcoronaryheartdiseasewererandomlydividedin
5、totheexperimentalgroup(30cases)andthecontrolgroup(30cases).EachgroupwastreatedwithWesternmedicineasaprimarytreatment.TheexperimentalgroupwasdosedJianpihuatanquyudecoction.Thecourseofclinicaltreatmentisfourweeks.Results:After4weekstreatment,anginapectoris,experi
6、mentalgroup,markedlyeffectiveratewas33.33%,totaleffectiveratewas76.67%;controlgroup,markedlyeffectiveratewas16.67%,totaleffectiveratewas50%.MedicineClinicalsymptomsoftheexperimentalgroupwasmarkedly33.33%,totaleffectiveratewas90%;markedlyeffectiveratewas16.67%in
7、controlgroup,thetotaleffectiveratewas60%.EKG,experimentalgroupthatwas30%,totaleffectiveratewas73.33%;markedlyeffectiveratewas16.67%incontrolgroup,thetotaleffectiveratewas43.33%.Thereweresignificantdifferences(P<0.05).Comparedwiththecontrolgroup,experimentalgrou
8、paftertreatment,Blood-fatandBloodRheologyweregreatlyimproved(P<0.01,P<0.01).Conclusions:Jianpihuatanquyudecoctionhasgoodcurativeeffectontreatinganginaofcoronaryheartdisease,