非小细胞肺癌的中医辩证分型与血清肿瘤标志物及病理分型的相关性研究

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1、提要目的:通过观察与非小细胞肺癌有关的血清肿瘤标志物的变化情况及其关病理分型，探讨两者与中医辨证分型之间的关系。方法:用多肿瘤标志物蛋白芯片检测系统测定57例原发性非小细胞肺癌患者和22例正常人血清中12项肿瘤标志物(CA19-9、CEA、NSE、CA242、CA153、CA125、free-PSA及PSA、Ferritin、AFP、HGH、HCG)的水平。结果:非小细胞肺癌组CEA、CA242、CA153、CA125、CA199浓度显著高于正常对照组(P<0.01)。CEA、CA242、CA153浓度的分布在三种证型中没有显著差异，(P>0.05)。CA125的浓度在正虚夹杂证中含量最高，

2、并按正虚夹杂型，正虚为主型、邪实为主型依次降低，并且在邪实为主型中，CA125含量低于其他证型(P<0.05)。CA199在邪实为主型中的浓度水平显著高于其它各组（p<0.01）,但正虚夹杂证、正虚为主型之间无显著差异。结论：病理类型与中医辨证分型间无明显联系。CEA、CA242、CA153、CA125、CA199是对非小细胞肺癌较有价值的标志物组合，与中医辨证分型也存在一定关系。关键词非小细胞肺癌;肿瘤标志物;病理分型;中医辨证分型。2ClinicalStudyonTheRelationofPathomorphologicalClassificationandTumorMarkersInd

3、icationLevelsofNonSmall-CellLungCancerWithItsDialecticClassificationInTraditionalChineseMedicineSpeciality:InternalMedicineofTCMAuthor:MengPengTutor:ProfessorQiYuanfuAbstractObjective:Observingthepathomorphologicalcassificationandtumormarkersindicationlevelsofnonsmall-celllungcancerinordertotherela

4、tionwiththedialecticclassificationintraditionalchinesemedicine.Methods:Detectlevelsof12tumormarkersof54pulmonarycarcinomapatientsand30normalpeoplebyC-12andcollectthepathomorphologicalresults.Results:TheindicationofCEA、CA242、CA125、CA153、CA199ofthepulmonarypatientsarehigherthanthoseofmormalpatients(P

5、<0.01).ThelevelofCEA、CA242、CA153don’thaveobviousdifferentioninthesixdialecticclassificationsintraditionalchinesemedicine(P>0.05).ThelevelofCA125consistsmostintheQideficiencyandphlegmdampness,andthendecreasefromthetwotypeofdeficiencyoflungandkidney,thetwotypeofdeficiencyofQiandYin,Qistagnationandblo

6、odstasistype,internalheatduetoyindeficiencytype,totheexcessiveheatandtoxintype,besidesthelevelofCA125inthelasttypeisobviousleast(P<0.01).ThelevelofCA199inQistagnationandbloodstasistypeisobviousexcessivethantheothers(P<0.01),whiletherestarewithoutobviousdiferentions.Conclusion:Squamouscarcinomaiscom

7、moninQideficiencyandphlegmdampnessandQistagnationandbloodstasistype,adenocarcinomaiscommonininternalheatduetoyindeficiencyandthetwotypeofdeficiencyofQiandYin,CEA、CA242、CA153、CA125、CA199isvaluablecompounding