effects of heavy ion radiation.pdf

effects of heavy ion radiation.pdf

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时间:2019-02-28

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1、Availableonlineatwww.sciencedirect.comAdvancesinSpaceResearch47(2011)37–48www.elsevier.com/locate/asrAmodeloftheeffectsofheavyionradiationonhumantissuea,b,⇑cdeArtemL.Ponomarev,AlameluSundaresan,MarceloE.Vazquez,PeterGuida,ebAngelaKim,FrancisA.CucinottaaUSRA,3

2、600SpaceCenterBlvd.,Houston,TX77058,USAb2101NASAParkway,HumanAdaptationandCountermeasuresDivision,MailCodeSK,NASAJohnsonSpaceCenter,Houston,TX77058,USAc3100CleburneSt.,DepartmentofBiology,TexasSouthernUniversity,Houston,TX77004,USAdNationalSpaceBiomedicalRes

3、earchInstitute,BaylorCollegeofMedicine,OneBaylorPlaza,Houston,TX77030-3498,USAeBrookhavenNationalLaboratory,Upton,NY11973,USAReceived8January2010;receivedinrevisedform9July2010;accepted9August2010AbstractInheavyionradiotherapyandspacetravelhumansareexposedto

4、energeticheavyions(C,Si,Feandothers).ThistypeofirradiationoftenproducesmoreseverebiologicaleffectsperunitdosethanmorecommonX-rays.AnewMonteCarlomodelgeneratesaphysicalspacewiththecomplexgeometryofhumantissueoracellculturebasedmodeloftissue,whichisaffectedbythe

5、passageofionizingradiation.Forirradiation,themodelreliesonaphysicalcodefortheiontrackstructure;fortissues,cellularmapsarederivedfromtwo-orthree-dimensionalconfocalmicroscopyimagesusingimagesegmentationalgorithm,whichdefinescellsaspixilatedvolumes.Themodelisus

6、edtostudytissue-specificstatisticsofdirectionhitsandtheremoteionactiononcells.Asanapplicationofthetechnique,weconsideredthespatialpatternofapoptoticcellsafterheavyionirradiation.Thepatternofapoptosisismodeledasastochasticpro-cess,whichisdefinedbytheactioncross

7、sectiontakenfromavailableexperimentaldata.Tocharacterizethedegreeofapoptosis,anautocorrelationfunctionthatdescribesthespatialcorrelationofapoptoticcellsisintroduced.Thevaluesoftheautocorrelationfunctiondemonstratetheeffectofthedirectionalityoftheradiationtrac

8、konthespatialarrangementsofinactivatedcellsintissue.Thiseffectisintrinsiconlytohighlinear-energy-transferradiation.Ó2010COSPAR.PublishedbyElsevierLtd.Allrightsreserved.Keywords:Heavyions;Tissueir

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