@Cancer Res-2006-Wang-10983-94[1].pdf

《@Cancer Res-2006-Wang-10983-94[1].pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、DOI:10.1158/0008-5472.CAN-06-2298GenerationofaStableAntioxidantResponseElement-DrivenReporterGeneCellLineandItsUsetoShowRedox-DependentActivationofNrf2byCancerChemotherapeuticAgentsXiuJunWang,JohnD.HayesandC.RolandWolfCancerRes2006;66:10983-10994.PublishedonlineNovember15,2006.Updated

2、VersionAccessthemostrecentversionofthisarticleat:doi:10.1158/0008-5472.CAN-06-2298SupplementaryAccessthemostrecentsupplementalmaterialat:Materialhttp://cancerres.aacrjournals.org/content/suppl/2006/11/13/66.22.10983.DC1.htmlCitedArticlesThisarticlecites48articles,21ofwhichyoucanaccess

3、forfreeat:http://cancerres.aacrjournals.org/content/66/22/10983.full.html#ref-list-1CitingArticlesThisarticlehasbeencitedby12HighWire-hostedarticles.Accessthearticlesat:http://cancerres.aacrjournals.org/content/66/22/10983.full.html#related-urlsE-mailalertsSignuptoreceivefreeemail-ale

4、rtsrelatedtothisarticleorjournal.ReprintsandToorderreprintsofthisarticleortosubscribetothejournal,contacttheAACRSubscriptionsPublicationsDepartmentatpubs@aacr.org.PermissionsTorequestpermissiontore-useallorpartofthisarticle,contacttheAACRPublicationsDepartmentatpermissions@aacr.org.Do

5、wnloadedfromcancerres.aacrjournals.orgonOctober28,2011Copyright©2006AmericanAssociationforCancerResearchDOI:10.1158/0008-5472.CAN-06-2298ResearchArticleGenerationofaStableAntioxidantResponseElement–DrivenReporterGeneCellLineandItsUsetoShowRedox-DependentActivationofNrf2byCancerChemoth

6、erapeuticAgents121XiuJunWang,JohnD.Hayes,andC.RolandWolf1CancerResearchUKMolecularPharmacologyUnitand2BiomedicalResearchCentre,NinewellsHospitalandMedicalSchool,UniversityofDundee,Dundee,Scotland,UnitedKingdomAbstractagainstcarcinogenicelectrophilesandreactiveoxygenspecies(ROS;refs.1,

7、2).ThisdefensecanbeinducedinresponsetoredoxTheNF-E2p45-relatedfactor2(Nrf2)regulatescytoprotectivestressors,therebyallowingcellstoadapttothepresenceofpro-genesthatcontainanantioxidantresponseelement(ARE)inoxidantsandelectrophiles.Itisalsooverexpressedincertaintheirpromoters.Toinvestig

8、atewh