心肌梗死与心室重构中mirna和转录因子共调控网络分析

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1、分类号学号I201221032学校代码10487密级硕士学位论文心肌梗死与心室重构中miRNA和转录因子共调控网络分析学位申请人：VUSUMUZILEROYSIBANDA学科专业：生物化学与分子生物学指导教师：郭安源教授答辩日期：2014年5月20日万方数据AthesissubmittedinpartialfulfillmentoftherequirementsforaMasterofSciencedegreeinBiochemistryandMolecularBiologyMicroRNAandTranscriptionFac

2、torregulatorynetworkanalysisinmyocardialinfarctionandventricularremodeling.Candidate:VUSUMUZILEROYSIBANDAMajor:BiochemistryandMolecularBiologySupervisor:ProfessorAn-YuanGuoHuazhongUniversityofScienceandTechnologyWuhan430074,P.R.ChinaMay2014万方数据OriginalstatementIdecla

3、rethatundertheguidance,accesstolaboratoriesmaterialsandresearchresults,thissubmitteddissertationismypersonalresearchwork;itdoesnotcontainanyofothersingularorgroupwrittenorpublishedresearchunlessthecontenthasbeenmarkedtothereference.Dissertationauthorsigned:Date:Disse

4、rtationcopyrightattorneyTothebestofmyknowledge,IfullyunderstandtheSchoolofLifeScienceandTechnologyrightsforthisdissertationreservation.Theschoolrighttoretainorinstitutiontothenationalauthoritiessentacopyofthepaperandelectronicversionofpaperstobeallowedtoaccessandborr

5、ow.IauthorizethisSchoolandHuazhongUniversityofscienceandtechnologytouseacopy,microprintandallmeansofsavingthisMasterofSciencedegreethesis,sothatitcanbeallorpartofthecontentintothedatabasetosearchforafutureuse.Thesisauthorsigned:InstructorSignature:Date:Date:万方数据华中科技大

6、学硕士学位论文AbstractMyocardialinfarction(MI)isaleadingcauseofdeathintheindustrializedworld,andthusdevelopmentofnewtherapeuticstrategiesisanimportantaimofbothclinicalandbasiccardiovascularresearch.ManygenesandbiologicalprocesseswerereportedtobeinvolvedinMIandtheregulationi

7、nMIisverycomplex.Here,wepursuedaregulatorynetwork-basedapproachforthecomprehensiveinvestigationofgeneregulationpatternsinMI.Firstly,wecompiledMIrelatedgenesandmiRNAsfrommultiplesources;PUBMED,CADgene,GWAS,HMDDandmiR2disease,whichincludedmultipletypesofvariationswithe

8、xperimentalproof.Then,weidentifiedthepotentialregulatoryrelationsforTF-MIgenes/miRNAsandMImiRNAs-MIgenes/TFs.FortheTF-MIgenes/miRNA