抗胸腺细胞免疫球蛋白治疗的心脏毒性及影响因素

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1、硕士学位论文non-lymphocyticleukemia(ANLL)25cases，acutemyeloblasticleukemia(AML)2cases，chonicmyelocyticleukemia(CML)30cases，mixed-lineageacuteleukemia2cases,myelodysplasticsyndrome(MDS)3Cases，aplasticanemia(AA)2cases，systemiclupuserythematosus(SLE)5cases，Mediterraneandisease4cases，pseudohypertrophyprog

2、ressivemusculardystrophy(PPMD)lcase，overlapsyndrome(systemiclupuserythematosus、dermatomyositis)lcase．Theyallhad110organicheartdiseasehistory,alsonoclinicalsymptomssuch嬲palmus、complaintatpraecordium、cheststressandbreathholding．Normalelectrocardiogram、aspartateaminotransfcrasc(AST)、creatinekinasc(

3、CK)andcreatinkinaseisozyme．Allthecasescanruleoutacutestageofmyocardialinfarction、pericarditis、myocarditisandotherkindsoforganicheartdiseases．MethodRecordthefundamentaldata：0)name(2)SeX(3)age(4)diabetes(5)cardiacstatus(6)clinicalmanifestationofcardiotoxity(7)accumulateddose(mg)(8)hemoglobinconcen

4、tration(g／L)(9)electrocardiogram(10)stemite(11)myocardialenzymes(CKandCK-MB)(12)malignanttBITIOr(13)electrolytedisturbances(14)radiotherapy(15)marcellomycins(16)busulfanum(Bu)(17)cyclophosphamide(18)Itraconazole(19)ciclosporinA(CsA)．Hematopoieticstemcelltransplantationgroupshouldrecordtransplant

5、ation(includingperipheralblood、bonemarrowandmixedhematopoieticstemcell们nSplaIltation)．Studyretrospectivelyofgeneralgroupaboutheartrate、bloodpressure、progressnoteandelectrocardiogram、stemite、myocardialenzymes，andsoon．Incidenceofhearteventssuchasbloodpressurechanges、arrhythmia、anginapectoriswithST

6、-TchangesandheartfailureWasstatisticallyanalised．Thesepatientsweredividedintotwogroupsbasedonifcardiomxit)，wasoccurred．GroupA：cardiotoxityWasoccurred，whichdisplayedaSchangesofcariacrhytlnn、function、ABSTRACTpericarditisorheighteningofmyocardialenzymes；GroupB：cardiotoxitywasnotoccurred．Univariatea

7、ndmultivariateanalysis(109isticregression)wel"eusedtoidentifytheaffectingfactors．Theriskfactorsofacuteheartfailure(AHF)becauseofATGwasinvestigatedasthesameway．RiskfactorsofcardiotoxityandAHFbecauseofATGforhematopoieticstemce