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ID:33604507
大小:6.18 MB
页数:61页
时间:2019-02-27
《tgf-β1及ras相关基因多态性与腰椎间盘突出症中医证型的关联研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、TGF-pl及RAS相关基因多态性与腰椎同盘突出症中医证型的关联研究5.ThepatientwithbloodstasispattemoftheLIDPofTGF-D1-509CTcarrierandACEIDcarrieraswellwereinhigherrisk;Thepatient谢thcoldhygrosispattemoftheLIDPwiⅡlATlRl166geneACcarrier,TGF—p-509CCcarrierwereinhigherriskthanLIDP谢tIlcoldhygrosispattern;Thepatien
2、tswithDeficiencyofbothLiverandKidneypattemofLIDP,andACEgeneIIcarrierwereinhigherrisk.Conclusions1.ThepolymorphismsofTGF·131-509、ACEandAT1RA166CarenotthesingleriskyfactortoLIDP,ThefamilyhistoryofLowBackPain,bodyfigureandwaistonloadenery(occupied)werethemainriskyfactorstoLIDP.2
3、.ThepolymorphismsofTGF—D1—509、ACEandATlRAl166CarerelevanttoIDD.PeoplewhocarriedTGF一131—509CT、ACEDDandAT1R1166ACmighthavemoreIDDrisk.Thatistosay,theTGF一509adiponectingeneandtheRASrelevantgenemighthaverelationtotheprogressofIDD,ACEgenewascorrelatedwiththeoccurrenceofLIDE3.TGF-B
4、1gene一509adiponectinCTgenotypeissusceptiblegeneofsyndromeofbloodstasispattemofLIDESeriouswaistunloadeneryisoneoftheriskfactorsofsyndromeofbloodstasispattemofLIDE4.ACEIIpolymorphismissusceptiblegeneofDeficiencyofbothLiverandKidneypatternofLIDP.5.ATlRl166ACgenotypeandTGF-131—50
5、9CCgenotypecarriercouldincreasetheriskofthecoldhygrosispatternofLIDE6.TGF一131—509CTgenotypeWasdominantinBloodstasispatternofLIDP,andtheseIDDcarryingwithTGF一131-509CTgenotypearemuchmoreseriou。.whetherthereWasrevelancebetweenLIDPandIDDWasneededfurtherresearch.7.TheACEI/Dpolymor
6、phismandAT1Rl166A/CpolymorphisminHanofGuangxiandZhuangaresusceptiblegenesignofLIDE8.ThereisnorevelancetobefoundbewteeBTGF·B1—800CgenotypeandLIDEThesubjectprovidessomeexperimentandclinicfoundationforTheTCMmolecularsyndromeofLIDPandoffersbasisonthefurtherresearch.Wetherrelevant
7、mechanismandsomeindexescouldbecomestandardsofthesyndromeofLIDPshouldenlargethesamplesizetofurtherreseach.6湖北中医学院2008届博士学位论文Keywords:Lumbarintervertebraldiskprotrusion(LIDP);Intervertebraldiscdegeneration(IDD);Transforminggrowthfactor131(TGF-131);Angiotensin-convertingenzyme(A
8、CE);AngiotensinIItyPe1receptor(AT1R】Syndromeoftraditionchinesemedini
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