tgf-β1及ras相关基因多态性与腰椎间盘突出症中医证型的关联研究

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1、TGF-pl及RAS相关基因多态性与腰椎同盘突出症中医证型的关联研究5．ThepatientwithbloodstasispattemoftheLIDPofTGF-D1-509CTcarrierandACEIDcarrieraswellwereinhigherrisk；Thepatient谢thcoldhygrosispattemoftheLIDPwiⅡlATlRl166geneACcarrier,TGF—p-509CCcarrierwereinhigherriskthanLIDP谢tIlcoldhygrosispattern；Thepatien

2、tswithDeficiencyofbothLiverandKidneypattemofLIDP，andACEgeneIIcarrierwereinhigherrisk．Conclusions1．ThepolymorphismsofTGF·131-509、ACEandAT1RA166CarenotthesingleriskyfactortoLIDP，ThefamilyhistoryofLowBackPain，bodyfigureandwaistonloadenery(occupied)werethemainriskyfactorstoLIDP．2

3、．ThepolymorphismsofTGF—D1—509、ACEandATlRAl166CarerelevanttoIDD．PeoplewhocarriedTGF一131—509CT、ACEDDandAT1R1166ACmighthavemoreIDDrisk．Thatistosay，theTGF一509adiponectingeneandtheRASrelevantgenemighthaverelationtotheprogressofIDD，ACEgenewascorrelatedwiththeoccurrenceofLIDE3．TGF-B

4、1gene一509adiponectinCTgenotypeissusceptiblegeneofsyndromeofbloodstasispattemofLIDESeriouswaistunloadeneryisoneoftheriskfactorsofsyndromeofbloodstasispattemofLIDE4．ACEIIpolymorphismissusceptiblegeneofDeficiencyofbothLiverandKidneypatternofLIDP．5．ATlRl166ACgenotypeandTGF-131—50

5、9CCgenotypecarriercouldincreasetheriskofthecoldhygrosispatternofLIDE6．TGF一131—509CTgenotypeWasdominantinBloodstasispatternofLIDP，andtheseIDDcarryingwithTGF一131-509CTgenotypearemuchmoreseriou。．whetherthereWasrevelancebetweenLIDPandIDDWasneededfurtherresearch．7．TheACEI／Dpolymor

6、phismandAT1Rl166A／CpolymorphisminHanofGuangxiandZhuangaresusceptiblegenesignofLIDE8．ThereisnorevelancetobefoundbewteeBTGF·B1—800CgenotypeandLIDEThesubjectprovidessomeexperimentandclinicfoundationforTheTCMmolecularsyndromeofLIDPandoffersbasisonthefurtherresearch．Wetherrelevant

7、mechanismandsomeindexescouldbecomestandardsofthesyndromeofLIDPshouldenlargethesamplesizetofurtherreseach．6湖北中医学院2008届博士学位论文Keywords：Lumbarintervertebraldiskprotrusion(LIDP)；Intervertebraldiscdegeneration(IDD)；Transforminggrowthfactor131(TGF-131)；Angiotensin-convertingenzyme(A

8、CE)；AngiotensinIItyPe1receptor(AT1R】Syndromeoftraditionchinesemedini