中性粒细胞弹性蛋白酶与其抑制剂对大鼠脑出血作用的实验研究

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1、重庆医科大学曛士研究生学位论文EXPERIMENTALSTUDYoFTHEEFFECToFNEINTIlERATINTRACEREBRALHEMORRHAGE(ICH)ANDTHEPRoTECTIoNoFSIVELESTATSoDIUMFRoM1’IIERATlCHABSTRACTOBJECTIVE=Hemorrhagestrokeisoneoftheseveretypeofacutebrainvasculardiseasewithhighrateofincidence，morbidityandmortality．Studiesshowthathemorrhagiccere

2、bralapoplexytakes10％～25％ofallkindofcerebralapoplexies．Exceptforthehematoma,thedepravationofthediseaseisusuallyrelatedtothesecondarydamageofperihematomatissue，suchasinflammatoryresponse，cerebralischemia，energymetablicdisorderandtheinjuryofoxygenfreeradical．Inclinicalpractice，thereisnoeffect

3、ivemethodtocurethisdiseasebecauseofitscomplicatedetiology．Sivelestatsodium，asynthesisspecificmicromolecularneutrophilelastaseinhibitor,canattenuateacutelunginjury．Clinicalresearchesshowthatsivelestatsodiumcallreducetheinjuryofbronchoaepitheliaandvascularendothiliuaconductedbyactivatedneutr

4、ophils，whatismore，sivelestatsodiumCandecreasethepermeabilityofvascularendothiliatorestrainhemorrhagiclunginjury．Inallkindsoflunginjurymodels，5重庆医科大学硕士研究生学位论文sivelestatcanamelioratethehemorrhageoflunginjury，proteinumexudationandpermeabilityofpneumoangiogram．Ithasreportedthatsivelestatsodium

5、cannotonlyamelioratetheedemaandtheinflammationresponseofcerebraltissuecausedbyischemia／reperfusioninjury，butalsoattenuatedneurologicdmageinrecentyears．Buttherehasnotreportedaboutitsprotectionfromtheinjuryofcerebraltissueinducedbyintracerebralhemorrhage．Becauseintracerebralhemorrhageandcere

6、bralischemia／reperfusionhavethesimilarinjury,includinginflammationresponse，cerebraledemaandchangeofcerebralbloodflow,SOwepresumethatsivelestatsodiumprobablyhaveprotectionfromintrcerebralhemorrhage。TheobjectiveoftheresearchistoinvestigatetheprotectiveeffectofsivelestatsodiumfromtheratICHind

7、ucedbyeollagenaseaswellastohaveapreliminaryprobeonthemechamism．METHODS：Animalmodelsweremadebyinjectingcollagenaseintocaudatenucleusofratcerebralwithmicroinjector,thenobservethedynamicchangeoftheNEconcentrationinthecerebraltissueandthebrainwatercontent；observet