中药活性成分姜黄素对乳腺癌细胞自噬和内质网应激通路的影响研究

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1、万方数据Curcumin，AnActiveIngredientExtractedfromChineseHerbs，RegulatesAutophagicandEndoplasmicReticulumStressPathwaysinHumanBreastCancerCellsADissertationSubmittedfortheDoctorateCandidate：ChenJianAdviser：Prof．TangJinhaiN删ingUniversityofChineseMedicine，Nanjing，China万方数据学号：20103072博士学位论文中药活性成分姜黄素对乳腺癌细胞自噬和

2、内质网应激通路的影响研究作者姓名陈健指导教师姓名唐金海学科专业中西医结合临床学习时间自2010年09月01日申请学位级别医学科学博士学位职称研究方向起至教授乳腺肿瘤外科疾病研究2014年12月31日止论文提交日期2014年12月11日论文答辩日期2014年12月05日学位授予单位南京中医药大学学位类型医学科学博士学位万方数据原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进行研究工作所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本声明的法律结果

3、由本人承担。学位论文作者(需亲笔)签名：，J日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权南京中医药大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密口，在一年解密后适用本授权书。本学位论文属于不保密囱。(请在以上方框内打“4”)学位论文作者(需亲笔)签名：导师(需亲笔)签名：V年肛月I／E1如-妒年，>月t1日万方数据目录中文摘要····································

4、··············⋯······iiiAbstract··················································⋯······vi符号及缩略语··································⋯·····⋯·····⋯·····ix前言······································⋯····················1刖舌·····。‘·························‘·····⋯····‘‘。。···。。。。‘··。‘第一部分理论研究··················

5、····⋯····⋯···············4第一章乳腺癌的研究背景··························⋯····⋯···4前言·············．·············································4刚舌‘‘‘。‘‘。‘‘。‘‘‘。。。。。‘‘‘。‘。。‘‘‘‘‘‘。。‘‘‘。‘‘。‘‘‘‘‘‘‘。‘。‘‘‘‘‘‘。。。1．流行病学研究·············································⋯-·····．42．遗传学研究········-··················⋯··⋯····

6、·⋯·············63．乳腺癌发病的危险因素······················⋯·············⋯-·74．乳腺癌预防策略·····················⋯···⋯······⋯·····⋯···9第二章乳腺癌中西医诊治的研究进展简介··-························11前言··························································1111日U舌。。‘。‘。‘‘。‘‘‘。‘。‘。。‘‘‘‘。。‘‘。‘‘‘。。。‘‘‘。‘‘。‘‘。‘‘。。‘‘。‘‘。‘。‘‘‘1．乳腺癌中医发

7、病机制及其治疗的研究进展····························112．乳腺癌西医治疗的研究进展·····································163．中西医结合治疗乳腺癌的研究进展·································18第三章中药活性成分姜黄素的研究概况·········⋯·················20前言·····