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时间:2019-02-26
《低钙透析液对持续性不卧床腹膜透析患者生存的影响.science》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、万方数据低钙透析液对持续性不卧床腹膜透析患者生存的影响曹陶邱亚桂熊丽萍徐庆东徐丰华林小燕余学清毛海萍【摘要】目的探讨低钙透析液对持续性不卧床腹膜透析(CAPD)患者生存的影响。方法收集2006年1月1日至2010年12月31日本院腹膜透析中心规律随访的CAPD患者临床资料,随访至2011年12月31日。根据使用透析液钙离子浓度的不同,将患者分为标准钙(1.75mmol/L)腹膜透析液(SCD)组和低钙(1.25mmol/L)腹膜透析液(LCD)组,通过COX回归分析两组患者的生存率及影响生存的相关危险因素
2、。结果共纳入982例CAPD患者,其中SCD组634例,LCD组348例。中位随访时间为24.20(3.07—72.87)个月,共有162例(16.5%)死亡,其中7l例(43.8%)死于心脑血管疾病。SCD组患者1年、3年和5年累积生存率分别为90.9%、74.2%和58.9%;LCD组患者1年、3年和5年累积生存率分别为98.6%、94.0%和76.4%。LCD组患者的生存率显著高于SCD组(P3、的独立危险因素;与标准透析液相比,低钙透析液是生存的保护因素。结论与标准钙透析液相比,CAPD患者使用低钙透析液的生存率更高;老龄、糖尿病和低血红蛋白水平是影响腹膜透析患者预后的独立危险因素。【关键词】腹膜透析;存活率;透析液;危险因素;钙磷代谢ImpactoflowcaldumdialysateonsurvivalincontinuousambulatoryperitonealdialysispafientsCAOToo,QIUYa-gui,XIONGLi-ping,XUQing-dong,XUFeng4、-hua,uNX沁一yan,YUXue··qing,MAOHai··ping.DepartmentofNephrology,TheFirstAffiliatedHospital,KeyLaboratoryofNephrology,MinistryofHealth,SunYat-senUniversity,Guangzhou5w080,ChinaCorrespondingauthor:MAOHai-ping,Email:haipingmao@126.com【Abstract】ObjectiveToinves5、tigatetheimpactoflowcalciumdialysateonsurvivalincontinuousambulatoryperitonealdialysis(CAPD)patients.MethodsCAPDpatientsatourPDcenterbetweenJanuary1,2006andDecember31,2010wereretrospectivelystudied.Thepatientsweredividedintostandard-calciumdialysate(SCD)g6、roupandlow-calciumdialysate(LCD)group.CoxregressionanalysiswasusedtocomparepatientsurvivalanddeterminetherelatedriskfactorsResultsAtotalof982eligiblePDpatientswereincludedinthisstudy,ofwhom634patientstreatedwithstandard—calciumdialysate,and348withlow-calc7、iumdialysate.Duringamedianf0U0w—up0f24.2.month,162(16.5%)died,71(43.8%)ofthemduetocardiovascularandcerebrovasculardiseases.Theoveralll-,3.,and5.yearpatientsurvivalrateswere90.9%,74.2%and58.9%inSCDgroupand98.6%.94.0%and76.4%inLCDgroup.Coxregressionanalysis8、demonstratedthatlowcalciumdialysatetreatmentreduced59%riskofa11.causedeath.ascomparedwithstandardcalciumdialysateexposure.Oldage,diabetesstatusandlowerhematoglobinwereindependentriskfactorsofa11.causedeathinCAPDpati
3、的独立危险因素;与标准透析液相比,低钙透析液是生存的保护因素。结论与标准钙透析液相比,CAPD患者使用低钙透析液的生存率更高;老龄、糖尿病和低血红蛋白水平是影响腹膜透析患者预后的独立危险因素。【关键词】腹膜透析;存活率;透析液;危险因素;钙磷代谢ImpactoflowcaldumdialysateonsurvivalincontinuousambulatoryperitonealdialysispafientsCAOToo,QIUYa-gui,XIONGLi-ping,XUQing-dong,XUFeng
4、-hua,uNX沁一yan,YUXue··qing,MAOHai··ping.DepartmentofNephrology,TheFirstAffiliatedHospital,KeyLaboratoryofNephrology,MinistryofHealth,SunYat-senUniversity,Guangzhou5w080,ChinaCorrespondingauthor:MAOHai-ping,Email:haipingmao@126.com【Abstract】ObjectiveToinves
5、tigatetheimpactoflowcalciumdialysateonsurvivalincontinuousambulatoryperitonealdialysis(CAPD)patients.MethodsCAPDpatientsatourPDcenterbetweenJanuary1,2006andDecember31,2010wereretrospectivelystudied.Thepatientsweredividedintostandard-calciumdialysate(SCD)g
6、roupandlow-calciumdialysate(LCD)group.CoxregressionanalysiswasusedtocomparepatientsurvivalanddeterminetherelatedriskfactorsResultsAtotalof982eligiblePDpatientswereincludedinthisstudy,ofwhom634patientstreatedwithstandard—calciumdialysate,and348withlow-calc
7、iumdialysate.Duringamedianf0U0w—up0f24.2.month,162(16.5%)died,71(43.8%)ofthemduetocardiovascularandcerebrovasculardiseases.Theoveralll-,3.,and5.yearpatientsurvivalrateswere90.9%,74.2%and58.9%inSCDgroupand98.6%.94.0%and76.4%inLCDgroup.Coxregressionanalysis
8、demonstratedthatlowcalciumdialysatetreatmentreduced59%riskofa11.causedeath.ascomparedwithstandardcalciumdialysateexposure.Oldage,diabetesstatusandlowerhematoglobinwereindependentriskfactorsofa11.causedeathinCAPDpati
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