酮咯酸氨丁三醇联合黄体酮治疗急性结石性肾绞痛的临床疗效评估

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1、酮咯酸氨丁三醇联合黄体酮治疗急性结石性肾绞痛的临床疗效评估黄彬刘丹通讯作者陈谦徐海涛刘纪宁王英四川省绵阳市屮心医院急诊科四川绵阳621000【摘要】冃的：评估酮咯酸氨丁三醇注射液联合黄体酮治疗急性结石性肾绞痛的止痛效果、24小时复发率及不良反应。方法：收集我院急诊科就诊的240例符合条件的急性结石性肾绞痛的患者，随机分为三个组，治疗组(A组)给予酮咯酸氨丁三醇60毫克加黄体酮20毫克，治疗组(B组)给予酮咯酸氨丁三醇30毫克加黄体酮20毫克，对照组(C组)给予盐酸哌替唳75毫克加黄体酮20毫克，治疗后0.5h、lh.2h进行疼痛程度评估，记录治

2、疗前后疼痛程度改变，观察药物副反应情况同时记录24小时复发率。结果:治疗组A组各观察时点0・5h、lh、2h内镇痛显效率分别为90.0%、95%、98.75%,治疗组B组观察时点0.5h、lh、2h内镇痛显效率分别为76.25%、93.75%、93.75%,对照组C组观察时点0.5h,lh,2h内镇痛显效率分别为91.25%、93.75%、93.75%,A组与C组患者各观察时点镇痛显效率差异无统计学意义(P>0.05)；A组与B组治疗后0.5h镇痛显效率差异有统计学意义(P<0.05),治疗后lh,2h内镇痛显效率差异无统计学意义,哌替唏

3、组不良反应明显多于治疗A组及B组，差异有统计学意义(P&t;0.05)o结论：酮咯酸氨丁三醇60毫克加黄体酮为急诊较理想的治疗肾绞痛方法，具有止痛效果好，副作用较少，24h复发率低的优点。【关键词】酮咯酸氨丁三醇；黄体酮；结石性肾绞痛；镇痛【屮图分类号1R473.6【文献标识码］B【文章编号11674-8999(2015)9-0568-02EvaluationoftheclinicaleffectsusingketorolactromethaminecombinedprogesteroneforacutecalculousrenalcolicH

4、uangBin,LiuDan,ChenQian,Xu-Haitao,LiuJi-ning,WangYingEmergencydepartmentofCentralHospitalofMianYang,China,621000【Abstract]Objective:Toevaluatetheclinicaleffectsusingketorolactromethaminecombinedprogesteroneforacutecalculousrenalcolic.MethodsAtotalof240casesofacuterenalcolicc

5、ausedbystoneswererandomlydividedintothreegroups„thetreatmentgroup(A)givenketorolactromethamine60mgplus20mgofprogesterone,treatmentgroup(groupB)givenketorolactromethamine30mgplus20mgofprogesterone,group(groupC)givenpethidinehydrochloride75mgplus20mgofprogesterone.toassessthed

6、egreeofpain.Visualanalogscale(VAS)wasusedtoassessthepainlevelsbeforeandaftertreatment.Sideeffectsandpainrelapsewithin24hourswererecordedaftertheinitialtreatments.ResultsGroupApainlevelswas90.0%,95%,98.75%afterobservationpoint0.5h,lh,2h.GroupBpainlevelswas76.25%,93.75%,93.75%

7、.GroupCpainlevelswas91.25%,93.75%,93.75%.GroupAandgroupCmarkedlyeffectivepainwasnosignificantdifferenee(P>0.05);GroupAandgroupBwasstatisticallysignificantaftertreatment0.5hour(P<0.05),Therewasnosign讦icantstatisticallysign讦icantaftertreatmentlh,2h.ThesideeffectsofGroupA

8、andgroupBwaslessthanCgroup.ConclusionKetorolactromethaminecombinedprogester