非定向诱导的颗粒松质骨-骨髓移植重建颌骨缺损的初步分析

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1、安徽医科大学硕士学位论文StudyofReconstructingJawDefectbyNon-directGuideOsteotransplantPostgraduate：BaiBingTutorProf．：YeMao-changConsultant,ProfessorAffiliatedAnhuiProvinceHospitalStomatologyCenterofAnhuiMedicalUniversityAbstractobjectiye：Itisfamiliarthattheresectionof

2、thettmlor,theextel删硒ury，theseverityostemyelifisc孤瑚criticalsizedefect(CSD)ofthejawboneintheclinic，鹤toit'shavetocarryonrepairingaconstruction．Thisresearchappliedtitanium(Ti)meshsupportwiththeParticulateeameellousboneandmarrow(PCBM)compoundempresstorepairingt

3、hedefectionofthejawbones，forunders锄dingtheeffectsbynoll-definitedirectionmarrowofbonereconstruction,toprovidethel'elatodfoundationandconclusionforsetupthebonesorganizationengineeringofprefabricated-mineralizedinducementfactorcompound．Methods：。1．Experiments

4、tudy：Toselect9femalegoatsa3experiment喇eets．Andtheangleofthegoatsmandibularbody、帆formedintothecritical(3．5‘2．0‘2．0cm)bonedefections．Adoptingoneselfmatched-pairsdesign,theleftsidedefectionareaplacedthegranacancellatcdboneandmarrowcompoundfromtheflankbone；the

5、rightsidebonedefectiondidn'tplacedanymaterialasblankcontrolgroup．Afterthe5安徽医科大学硕士学位论文operation,thegoatswereexecuted1，3，6monthsrespectivelyfortheclinicalobservation,x-raycheckingandthehistologyobservation．2．Clinicalstudy：FromJan．200ltoDec．2002，13jawbonedef

6、ectedpatients(9menand4women)wereobservedwhoappliedthePCBMandthetitaniummeshforrecons拉uc吐onofthejawbones．Theyhadbeenvisitedfor6-20months．Thewoundhealingandthegraflwereobserved,andcheckedbytheX-ray．Resnlb：1．Experimentstudy：Goatshadbeenaliveduringobservationp

7、eriodbesidesonegoatdiedbecauseoftheanaesthesiaaccident．TheoperativeincisionsWel'eprimaryintentionhealing．ThroughtheX-rayandtheorganizationpathology,thesideofexperimenthadagreatdealofthefiberkindorganization,whilethesideofcomparisonhadbom110obviousorganizat

8、ion．2．Clinicalstudy：the13patienmwereallbeenfollow-upvisited．Theshapesofthepatients’jawbonesweferecoveredasthenormalon船．Thedonorsitehadnotabnormalorfunctionobstacle．Showedbythex-ray,thedensityofthebonewhichwas