替莫唑胺同期全脑放疗治疗脑转移瘤的疗效观察-(5920)

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1、山西医科大学硕士学位论文6例；单纯全脑放射性治疗组治疗有效率为54.17%，其中有3例完全缓解，统计值P<0.05提示两组间差别有意义。AB两组患者的生存率分别为56.25%和29.17%，p<0.05提示有差异。结论：转移性脑瘤患者使用替莫唑胺联合全脑放射治疗（A组）的毒副反应与单纯放射治疗（B组）相比，只有在白细胞计数中两组间差异，p<0.05提示有意义，但患者可耐受。A组的近期疗效优于B组，同时A组与B组相比显著提高了患者的1年生存率。关键词:替莫唑胺；同期放化疗；脑转移瘤；全脑放疗II山西医科大学硕士学位论文Temozolomideperiodwholebrainradioth

2、erapyefficacyinthetreatmentofbrainmetastasesAbstractObjective:Byobservingoraltemozolomidesynchronizedwholebrainradiotherapyisnotsequentialchemotherapytreatmentefficacyandtoxicityofbrainmetastases.Analyzedusingstatisticalmethodstoputnearlysynchronousbrainmetastasesafterchemotherapyarenotlong-term

3、efficacyofsequentialchemotherapyandtoxicity.Brainmetastasesaresummarizedsuitableindividualizedtreatmentplan.Methods:CollectedinJanuary2011toDecember2013attheSecondAffiliatedHospitalofShanxiMedicaltreatmentmettheinclusionandexclusioncriteria,40patientswithbrainmetastases.Thesemedicalrecordscollec

4、teddetailedstatisticalanalysis.Accordingtothedifferenttreatmentmethodssuffererswouldbedividedintotemozolomideconcurrentchemoradiotherapygroup(groupA)andradiotherapygroup(groupB).Twogroupsofsuffererswereperformedlinac6mV-Xlineofwholebrainradiationtherapy.Towholebrainradiationtherapymethods:fromth

5、eleftandrightsideirradiatedthesamecenterofthewholebrain,DT30Gy/10,5times/week.Agroupofpatientsgivenorallyduringthesameperiodinthewholebrainradiotherapywithtemozolomide75mg/(m2·d)chemotherapy,fortaking14d,untiltheendofradiotherapy.Results:Temozolomidesameperiod16casesofwholebrainradiotherapygroup

6、,including12malesand4females,aged38-70yearsold(54.94±2.39);radiotherapy24cases,includingIII山西医科大学硕士学位论文15malesand9females,aged35-74yearsold(53.29±2.22).Primarydiseasepatientsweremainlyfromnon-smallcelllungcancer(19cases),followedbysmall-celllungcancer,breastcancer,gastrointestinaltumors;twogroup

7、sofpatientswithbrainmetastasesmultiplemetastasesmainly.Aboveinformationbetweenthetwogroupsbychi-squaretest(pvalue>0.05)orttest(p>0.05),therewasnostatisticallysignificant.TemozolomideearlierWholebrainradiotherapywithWholebrai