胰岛素控制下糖尿病大鼠快速上颌扩弓后的骨代谢变化

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1、英文摘要Thechangeofbonemetabolismofthetreatmentwithinsulinontherapidpalatalexpansionofratssufferingfromdiabetesmellitus．ABSTRACTobjecfive：Withtheimprovementoflivingstandard。themorbidityrateofDiabetesmeUitus(Dlvl)isincreasing．TheageofpeoplewhosufferfromDiabetesmellitustendstobeyounger．Manyo

2、rthodonticdoctorshaveattachedimportancetoDMsufferers’orthodontictherapy．Rapidpalatalexpansion(RPE)is'usedwidelyinclinic．ThatDMsufferersoftenhaveosteoporosiswhichCanaccelerateassimilatorofbonewinmakedisadvantageonRPE．SoitisnecessarytoprovideslotsofevidenceofscienceandstatisticstoDMsuffe

3、rers’RPEtherapy。applyinginclinicbyanimalexperiment．ThepurposeofthisstudyistosetupananimalmodelofhelixexpansionandexploreeffectandbonemetabolismofRPEamongnormalrats，DMratsandInsulintreatedrats．Fundamentalexperimenttheoryisprovidedandservedtoclinic．‘Method：Seventy-twomaleSDrats(5weeksofa

4、ge)whoseweightrangefrom200to220gramswerechosenandrandomlygroupedintothreegroupsof24rats，GroupA，thenormolgroup；GroupB，diabetesgroupandGroupC，Insulintreatedgroup．Eachgrouprandomlygroupedintotwolittle’groups，theexpansiongroupof8ratsandretentiongroupof16英文摘要rats。Streptozotocin(STZ)wereceli

5、oinjectedinratsofGroupBandGroupCwiththeamountof60mgperkilogram．RatsinGroupAwereinjectedwiththesameamountofsodiumcitrate．Seventy—twohourslater,bloodwasextractedfromcaudalveinandurinewassamplebeforebloodglucoseandurinaryglousewererespectivelytested．Thoseratswhosebloodglucosewereabove16．7

6、mmolFLandurinaryglucosewerethreeplustofourplusarediagnosedasdiabetes．FourdaysafterthemodelofdiabetesmellitusWassucceeded，ratsinGroupCbegantoreceivesubcutaneousinjectionattheirnecks．TheamountofinjectionWasadjustedaccordingtotherats’bloodglucoseandurinaryglucosetillthebloodglucosewas8-10

7、mmol／L．GroupAandGroupBweregiventhesameamountofnormalsalineinjection．Twenty-onedaysafterthemodelofdiabetesmellitusWasestablished，alloftheratswereequippeddeviceofRPE．Helixspringsweremadeby0．45ramdiameterstainlesssteelandproduce2009forcebyextendarchwireabout5mm．ThearchwireisaboutlOmmlon