血浆部分氨基酸浓度与线粒体基因突变与糖尿病关系的探讨

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1、天津医科大学硕士学位论文ABSTRACTObjec妇ve：S咖er骼earchdemo璐tmt皓，the蕾utamate，whichareinthemitochon“aofg腿nul鼯，thusiⅡnuenceinsuliⅡsec—i∞．Themitoch呻d—al5tnIctll您andf岫cUona‘伐币60nmIycansuppr鹤s也egluc惦et0s吐邮Iatetheisletofl蛐驴rh蛐sceIItopmducethegIutamicadd，n岫uyamc虹thej璐lllinsec“蜘n．andthenc躺estheoccuntnceoft

2、hemabeteswithmitochondr

3、age岫mu协H蛐s，∞n∞nbes咖，themitochondrtaIstmct．1聆isexc印Ⅱ佃aHypo酾ibIy叫eoffh咖璐，wmch强ninnu蚰∞partialme切【bo№mofaminoadd．Thenf0托山epurposeofthisres腿rdhisto躺辩ssthe比la60nshipam蚰gthemitochonddag阻emutaⅡons，击abeteswitIImitochoIId—a群nemu纽廿蛐s8ndthemetab0ⅡsmOfaminoacminord盯toprov

4、idemeb酗IsfhrtheclinicalwDrkf2s卺arch。Method：T0Ⅱ擞蛳rethepI髓maami啪acidsin92h吼Ithyindivid岫b，l繇2TDM鲫bjectsand35轴bjectswhoh嬲mitochond—a弘北mutaUonsbyrHPI￡．Thepart重8Iaminoac量dshasbeenanaly弛dand∞mpandwitheachgr岬Reslllb：1．Wh胁墟e黼mplesa件mlores∞ncederivatedwltho·ph缅aIdialdebyde觚del劬蛆withthedt瑚te，t

5、heacetatebu仃ersoIuti蚰，alIs舢pI铺h盯ethegoodsepa聃t王one仃ectbyuslngd口LCt0detectpartjalaminoaddswMc：his啪n佻tedwi也me毋utanicacmmetabolismorh淞innuennalf．1nctionto．msIll．ms盹Rt．on．Thl婢me田utalIlcaddasthe既ample，its．d．天津医科大学硕士学位论文lowestIimitofdetec恤mis1ⅡⅢ．theRetention髓mecoemcientofvariatiOnme蛐value

6、andtheP色akAI蚰coefndent0fva—a6蚰mean他menspectIveIybe1．18舳士O．5吣6蛐d2．0“0±1．25∞，聪tums-聃tiobetwe饥95．34％一105．62％．2．Illmabet％other5ldndsofaminoadd∞nte】呲嬲辄me恤emganvecormIaHonwi也thesaccha一矗饥H蛐he咖gloMn，(r=·0．245，p_O．Ol；r=-0．259，p=O．010；r=-O．1粥，p=O．惝；r；-0．213，p=O．033；r=-0．215，p=O．们2)besmesme嬲pa

7、砌cacmandmeglu妇nic眦id，anddmpsalongwithmesacch一矗∞廿0nhemogIOMninc瑚se．HoweveBthe鼬aminOacldsdonothavemecOr弹IaHOnw量thotherIn№pendentva—aM豁．3．R耀ardingh姐lthyindiVid眦ls，蛐ly也ehistim耻∞ntentpre卵n拓廿地∞mlan蛐稍mb躯diⅡeiⅡ娜UnleveI，(r=O．286，p=O．02”alo雌wimhinmine∞ntentIncI屯ase．baseIineinsuUnleveIincItase

8、Butbehn}enoth盯蛐inOacids肌dtheinmlp蚰d姐tV村妇bIedonothavethecOrrelatIonaIdependenOe．4．PatienbwimmnochoⅡd—al辨ne删咀tanOns，diabet髂witlImitOchOnd—ag吼emutaHo眦：o山ytheIatterwh嬲eamiⅡoacm∞砸蛐t(麟p∞蜢veIyisr=-O．253，p=0．010；r=·0．273，p=O．027；r=．o．1鸸，p=O．043；r=·0．223，p=0．∞0；r=-0．234，p=O．∞5)assum馏men％at

9、v

10、ecor弛IaⅡonwi也thesac