脑浅静脉系血流动力学物理模型的建立及其意义

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1、安檄医科大学硕士学位论文邓雪飞结论①成功建立了脑浅静脉系血流动力学物理模型。②脑浅静脉有害形态特征之一为脑浅静脉注入硬脑膜窦角度量600、直径耋2．0ranl并且未经脑膜静脉或流出口狭部注入，有害形态特征之二为脑浅静脉注入硬脑膜窦角度>600、直径---->2．0mill并且经脑膜静脉注入。此时，脑浅静脉系局部血管壁面剪切力显著降低，脑静脉血栓形成容易发生。⑧血栓好发部位位于距注入处10min范围内的注入处上游脑浅静脉管壁和注入处下游硬脑膜窦壁；相对于硬脑膜窦，血栓更易发生于脑浅静脉管壁。④随着脑浅静脉直径的增大，脑浅静脉系血管壁面

2、剪切力降低更为明显，降低的范围更大，脑静脉血栓形成发生的机率增加，血栓更易发生于注入处上游脑浅静脉管壁。⑤硬脑膜窦入口压力和脑浅静脉入口压力比值增加后，脑静脉血栓形成发生的机率下降。关键词脑浅静脉系脑静脉血栓形成湍流壁面剪切力计算流体力学4安徽医科大学硕士学位论文邓雪飞TheestablishmentofthehemodynamicphysicalmodelsofthesuperficialcerebrovenoussystemanditsimplicationAbstractobjeefivasToestablishthehemo

3、dynamicphysicalmodelsofthesuperficialcerebro-venoussystemwiththemethodsofcomputefluiddynamics(CFD)，andtoprovidemorphologicbasisforthegenesisofcerebralvenousthrombosis(CVT)andtheirearlydiagnosis．MethodsBasedontheresuitofcadaversandneuroimagingandtheCFDsoftwarepack—FLUEN

4、TandGAMBIT,thehemodynamicphysiealmodelswereestablished．Thehaemodynamicparameterssuchasturbulence，wallshearstress(wss)andvelocitywerecarefullystudiedandcomparedbetweendifferentmodels．Results1．Fivegroupsandeighty-eightmodelsweTeestablished,includingthephysicalmodelsofsup

5、erficialcerebralveins(SVs)withvariousanglesdrainintotheduralsinus,themodelsofSVswithvariousdiametersdrainintotheduralsinus，themodelsofSVsdrainintotheduralsinusviameningealveins，themodelsofSVsdrainintotheduralsinusviaoutflowcuff,andthemodelsofSVswitlldifferentboundaryco

6、nditions．2．ThephysicalmodelsofSVswithvariousanglesdrainintotheduralsinusQ)ThegraphsbetweenvariousanglesandWSSwereobtained．Accordingtothegraphs，themodelsweredividedintothreegroups、】l，itllthedifferentangles：[100，60。】groups，(60。，1000)groupsand【100，170】groups．②Inthe[10。，60

7、。]groups，theturbulenceWasfoundintheduralsinuswithin3．9士1．1nunawayfromduralentranceandtheSVswithin4．3*4．2mmawayfromduralentrance．TheWSSinthedownstreamwallofduralsinus(DS趴andtheupstreamwallofsuperficialcerebralveins(SVU)besidestheturbulencedecreasedandwasbelowthereferenc

8、evaluefO．040Pa)．TheminimumWSSinDSD5安徽医科大学硕士学位论文邓雪飞andBVUWaS0．022士0．001Paand0．010-j=0．010Pa．田1elaterwaslowerthanformer