丹参酮i抗血管生成作用和机制研究

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1、缩略词表缩略词表ATCCAmericanTypeCultureCollection美国细胞库CAMchickchorioallantoicmembrane鸡胚尿囊膜HIFhypoxia-induciblefactor缺氧诱导因子HMEChumanmicrovascularendothelialcell人微血管内皮细胞HUVEChumanumbilicalveinendothelialcell人脐静脉内皮细胞IC5050%inhibitoryconcentration50%抑制浓度ODopticaldensity光

2、密度SDstandarddeviation标准差Tan-1tanshinone-1丹参酮ⅠTAItumorangiogenesisinhibitor肿瘤新生血管生成抑制剂VEGFvascularendothelialgrowthfactor血管内皮生长因子VI目录目录第1章引言...............................................................................................................1第2章丹参酮Ⅰ的

3、新生血管生成抑制作用.............................................................42.1前言.................................................................................................................42.2材料与方法............................................................

4、.........................................52.2.1药品与试剂...........................................................................................52.2.2主要仪器...............................................................................................52.2.3细胞培养.

5、..............................................................................................52.2.4细胞增殖抑制试验...............................................................................52.2.5血管内皮细胞迁移试验........................................................

6、...............62.2.6血管内皮细胞的管腔形成试验...........................................................62.2.7大鼠动脉环试验...................................................................................72.2.8鸡胚脲囊膜试验.........................................................

7、..........................72.3结果.................................................................................................................72.3.1丹参酮Ⅰ抑制血管内皮细胞增殖生长作用........................................72.3.2丹参酮Ⅰ抑制血管内皮细胞的迁移.............................

8、.......................82.3.3丹参酮Ⅰ抑制血管内皮细胞管腔形成作用........................................92.3.4丹参酮Ⅰ抑制大鼠动脉环微血管出芽作用....................................102.4小结.................................