neuregulin与radial glial scaffold——neuregulin调节及维持海马齿状回区域radial glial scaffold的研究

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1、分类号——UDC密级编号中国科学院博士学位研究生学位论文Neuregulin-星radialgliaiscaffold．==堂坠堡盟墅旦遢苴厘缝挂整里选达回区域塑壅逊g堑璺!§塑墅丛数班宜塑昌堑指导教师墨挞童堑宣虽一虫国抖堂堕弛垒型堂班煎逝申请学位级别谴±学科专业名称弛经!巳塑堂论文提交日期2QQ§生5旦l§旦论文答辩日期2QQ§生5旦!Q旦培养单位空圈抖堂医土涟生佥型堂班耋医擅垒压学位授予单位～生国挝堂医型窒生瞳答辩委员会主席工d!趣婴筮旦图表目录Figure1Distributionofrad

2、ialglialscaffoldinpostnatalratcerebralcortex26Figure2Distributionofradialglialscaffoldinposmatalrathippocampus27Figure3Functionofradialglialscaffold28Figure4ExpressionofErbB4inradialglialscaffoldinpostnatalhippocampusdentategYms．31Figure5Morphologyofc

3、ulturedhippocampusslices33Figm'e6Radialglialscaffoldindentategymsofculturedhippocampusslices36Figure7ExpressionofErbB4indentategymsofculturedhippocampusslices38Figure8EffectsofNeuregulinonthecellproliferationinthehippocampusslices。41Figure8EffectsofNe

4、uregulinonthecellproliferationinthehippocampusslices。42Figure9ComparationoftheBrdUincorporationeventbetweenNRGandEGFinthehippocampusdentategyms．44Figure10TheproliferatedcellstreatedbyNRGaFeRGCsinhippocampus．47Figure11Neuregulintreatmentincreasedtheexp

5、ressionofNestinproteininhippocampus．49Figure12NeuregulintreatmentincreasedproliferationofVimentin．positiveRGCsintheDGareaofhippocampus．51Figure13EffectsofNeuregulinonthecellproliferationinthedentategymsexplants．53Figure13EffectsofNeuregulinonthecellpr

6、oliferationinthedentategymsexplants．54Figure14BothMAPKandP13KarerequiredforNeuregulin—enhancedproliferationinhippocampusdentategyros．56Figure15NRG-treatmentdidnotaffectsurvivalofcellsinhippocampusdentategyrus．57Figure16EffectsofNeuregulininmaintaining

7、thecharacteristicmorphologicalfeaturesofRGCs．59Figure17Time—lapseshowedtheeffectsofendogenousNRGinmaintainingthecharacteristicmorphologicalofRGCs．61Figure18EffectsofendogenousNRGinmaintainingthecharacteristicmorphologicalofRGCsincultureddentategyrasex

8、plants．63Figure19RolesofNRG—ErbB4interactioninradialgliatscaffoldinhippocampusdentategyrus．69Figure20Differentnameofradialglialcells74Figure21Distributionofradialglialscaffoldinpostnatalratcerebralcortex77Figure22Schematicdiagramoftheevolvingc