comparative clinical study of chongqing czb high intensity focused ultrasound (hifu) therapeutic device with intranasal steroids and h1-antihistamine in treating allergic rhinitis patients论文

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1、重庆医科大学硕士学位论文COMPARATIVECLINICALSTUDYOFCHONGQINGCZBHIGHINTENSITYFOCUSEDULTRASOUND(HIFU)THERAPEUTICDEVICEWITHINTRANASALSTEROIDSANDH1--ANTIHISTAMINEINTREATINGALLERGICRHINITISPATIENTS姓名：GOBINPRITTY申请学位级别：硕士专业：耳鼻咽喉科学指导教师：胡国201205重庆医科大学硕士研究生学位论文COMPARATIVECLINICALSTUDYOFC

2、HONGQINGCZBHIGHINTENSITYFOCUSEDULTRASOUND(aImtJ)THERAPEUTICDEVICEWITHINTRANASALSTERoIDSANDH1．ANTIHISTAMINEINTREATINGPERSISTENTALLERGICRHINITISPATIENTS．ABSTRACTObjective：TocomparetheclinicaltherapeuticeffectofChongqingHi曲IntensityFocusedUltrasound(HIFU)therapeuticdev

3、icewithintranasalsteroidsandHI-antihistaminesintreatingpersistentallergicrhinitispatients．Design：ControlledProspective．Methods：95PatientsattendingENTOPDfromJune201uptoFebruary2012whohadbeendiagnosedasmoderate-severepersistentallergicrhinitis(PER)inaccordancetoARIAgu

4、idelines(2010revised)．Theenrolledpatientsweredividedinto2groups：group1andgroup2．63patientswereingroup1andtreatedbytheCZBultrasoundtherapeuticdevicedevelopedandproducedbyChongqingHaifu(HIFU)and32patientswereingroup2andtreatedwithintranasalsteroids(Fluticasonepropiona

5、te)andantihistamines(Loratadine)．Thebenefitswereobservedonthefirstday,1stweek，4thweeksand12mweek，assessingimprovementineachindividualnasalsymptom．2重庆医科大学硕士研究生学位论文EfficacyMeasurements：Thetherapeuticeffectwasevaluatedbytotalnasalsymptomscore(TNSS)andRhinitisQualityofL

6、ife(RQoL)，pretreatment(week0)andposttreatments(4weeksand12weeks)．Results：ThetotaleffectiverateofHIFUwas35．53％after1week，82．73％after4weeksand82．24％after12weekswhereasforthecontrolgroupthetotaleffectiveratewas63．61％after1week，81．29％after4weeksand77．55％after12weeks．Dif

7、ferenceswerestatisticallysignificant(p<0．05)whensymptomsscoreswereassessedseparately．Conclusions：HIFUhasproventobeaseffectiveandsafetoolinthetreatmentofallergicrhinitisasconventionaldrugtreatmentproposedbyAIUAguidelineswithminimalsideeffects．Thelongtermtherapeuticef

8、fectincomparisontoINSandantihistaminesneedtobefurtherstudied．Keywords：Allergicrhinitis，HIFU，intranasalsteroids，antihistamines3重庆医科大学硕士研究生学