益心清热法对老年冠心病心绞痛的临床研究

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1、提要目的：观察应用益心清热法治疗老年冠心病心绞痛的临床疗效，并探讨其作用机理。方法：采用随机分组的方法，将符合纳入标准的60例老年冠心病心绞痛患者分为治疗组和对照组两组，每组各30人。治疗组采用单硝酸异山梨酯片（鲁南欣康）常规治疗加益心清热汤治疗，对照组采用单硝酸异山梨酯片（鲁南欣康）治疗，6周为一个疗程，观察一个疗程。治疗前后检测患者白细胞介素1(interieukin-1，IL-l)与白细胞介素6(interleukin-6，IL-6)水平、肿瘤坏死因子(TNF)、hs-CRP等生化免疫指标及患者的症候变化情况。结果：治疗组治疗后中医症状总疗效

2、与对照组相比，有显著性差异（p＜0.05)。治疗组能明显减少心绞痛的发病率，能明显降低IL-1，IL-6，TNF，hs-CRP水平，与对照组相比，有显著性差异（p＜0.05)。治疗组血脂水平较对照组改善明显，有显著性差异（p＜0.05)结论：益心清热法具有调节炎性细胞分泌炎性因子，抑制炎症反应及稳定粥样斑块的作用，改善患者血脂水平，能够显著缓解冠心病心绞痛的发作，是治疗老年冠心病心绞痛的一种安全有效的方法。关键词心绞痛；益心清热；炎性因子；ClinicalResearchofanginapectorisofsenileCHDTreatedbythe

3、methodofHeartclearheatmethodSpeciality：InternalMedicineofTraditionalChineseMedicineAuthor：FangLi-wenTutor：Prof.BaoPei-rongAbstractObjective:ToobservetheapplicationmethodofheartclearheatmethodtreattheclinicalcurativeeffectofanginapectorisofsenileCHD,anddiscussthemechanismofacti

4、on.Methods:Randomizedprinciples,sixtyconformingtoStandardpatientsofelderlycaseswithanginapectoriswererandomlydividedintotreatmentgroup(30cases)andcontrolgroup(30cases).ThetreatmentgroupusedIsosorbideMononitrateroutinetreatmentandyixinqingre-Tang.AndthecontrolgroupusedIsosorbid

5、eMononitratetreatment.6weeksforaperiodoftreatment,observeaperiodoftreatment.ThechangesoflaboratoryindexesthatincludingIL-1、IL-6、TNF、hs-CRPandclinicalsymptomwereobservedbeforeandaftertreatmentinbothgroups.Results:AfterthetreatmentgroupisthetotalcurativeeffectoftraditionalChines

6、emedicinesymptomscomparedwiththecontrol，therearesignificantdifferences.Thetreatmentgroupcansignificantlyreducetheincidenceofangina,canobviouslyreduceIL-1,IL-6,TNF,hs-CRPlevel,comparedwiththecontrol,therearesignificantdifferences.Conclusion:Themethodwhichcanadjustinflammatoryce

7、llssecreteinflammatoryfactor,restraininflammationandstableatheromatousplaqueeffect,cansignificantlyeaseofCHDanginapectorisattack,isasafeandeffectivemethodtotreatanginapectorisofsenileCHD.Keywordsanginapectoris；Heartclearheatmethod；Inflammatoryfactor目录引言........................

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