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ID:33147890
大小:377.49 KB
页数:44页
时间:2019-02-21
《益心清热法对老年冠心病心绞痛的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、提要目的:观察应用益心清热法治疗老年冠心病心绞痛的临床疗效,并探讨其作用机理。方法:采用随机分组的方法,将符合纳入标准的60例老年冠心病心绞痛患者分为治疗组和对照组两组,每组各30人。治疗组采用单硝酸异山梨酯片(鲁南欣康)常规治疗加益心清热汤治疗,对照组采用单硝酸异山梨酯片(鲁南欣康)治疗,6周为一个疗程,观察一个疗程。治疗前后检测患者白细胞介素1(interieukin-1,IL-l)与白细胞介素6(interleukin-6,IL-6)水平、肿瘤坏死因子(TNF)、hs-CRP等生化免疫指标及患者的症候变化情况。结果:治疗组治疗后中医症状总疗效
2、与对照组相比,有显著性差异(p<0.05)。治疗组能明显减少心绞痛的发病率,能明显降低IL-1,IL-6,TNF,hs-CRP水平,与对照组相比,有显著性差异(p<0.05)。治疗组血脂水平较对照组改善明显,有显著性差异(p<0.05)结论:益心清热法具有调节炎性细胞分泌炎性因子,抑制炎症反应及稳定粥样斑块的作用,改善患者血脂水平,能够显著缓解冠心病心绞痛的发作,是治疗老年冠心病心绞痛的一种安全有效的方法。关键词心绞痛;益心清热;炎性因子;ClinicalResearchofanginapectorisofsenileCHDTreatedbythe
3、methodofHeartclearheatmethodSpeciality:InternalMedicineofTraditionalChineseMedicineAuthor:FangLi-wenTutor:Prof.BaoPei-rongAbstractObjective:ToobservetheapplicationmethodofheartclearheatmethodtreattheclinicalcurativeeffectofanginapectorisofsenileCHD,anddiscussthemechanismofacti
4、on.Methods:Randomizedprinciples,sixtyconformingtoStandardpatientsofelderlycaseswithanginapectoriswererandomlydividedintotreatmentgroup(30cases)andcontrolgroup(30cases).ThetreatmentgroupusedIsosorbideMononitrateroutinetreatmentandyixinqingre-Tang.AndthecontrolgroupusedIsosorbid
5、eMononitratetreatment.6weeksforaperiodoftreatment,observeaperiodoftreatment.ThechangesoflaboratoryindexesthatincludingIL-1、IL-6、TNF、hs-CRPandclinicalsymptomwereobservedbeforeandaftertreatmentinbothgroups.Results:AfterthetreatmentgroupisthetotalcurativeeffectoftraditionalChines
6、emedicinesymptomscomparedwiththecontrol,therearesignificantdifferences.Thetreatmentgroupcansignificantlyreducetheincidenceofangina,canobviouslyreduceIL-1,IL-6,TNF,hs-CRPlevel,comparedwiththecontrol,therearesignificantdifferences.Conclusion:Themethodwhichcanadjustinflammatoryce
7、llssecreteinflammatoryfactor,restraininflammationandstableatheromatousplaqueeffect,cansignificantlyeaseofCHDanginapectorisattack,isasafeandeffectivemethodtotreatanginapectorisofsenileCHD.Keywordsanginapectoris;Heartclearheatmethod;Inflammatoryfactor目录引言........................
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