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ID:33143478
大小:3.83 MB
页数:35页
时间:2019-02-21
《正己烷对人外周血淋巴细胞dna损伤的人群调查及神经行为功能测试研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、浙江大学硕士学位论文正己烷对人外周血淋巴细胞DNA损伤的人群调查及神经行为功能测试研究姓名:胡璐璐申请学位级别:硕士专业:劳动卫生与环境卫生学指导教师:王菁20120519浙江人学硕:l=学位论文中文摘要正己烷对人外周血淋巴细胞DNA损伤的人群调查及神经行为功能测试研究浙江大学医学院劳动卫生与环境卫生学MPH研究生导师胡璐璐。王菁副教授中文摘要【摘要】目的用丫H2Ax识别抗体流式细胞术检测接触正己烷作业工人对人外周血淋巴细胞DNA的损伤,探讨正己烷的遗传毒性.用中文计算机化神经行为测试软件检测接触正己烷作业工人神经行为功能,探讨和验证低浓度职业正己烷接触致工人神经系统隐匿性损害的可能性,及
2、神经行为功能测试反映神经系统早期损伤的可行性.方法提取某印刷公司接触正己烷工人33例(接触组)和该公司未接触正己烷工人17例(内对照组)及某非职业接触有害因素居民52例(外对照组)的外周血淋巴细胞,采用FCM法检测淋巴细胞DNA损伤情况.同时,从该工厂选择32名接触正己烷的工人(接触组)与32名未接触正己烷的工人(对照组),对两组进行神经行为功能测试.结果接触组、内对照组、外对照组DNA损伤率均数差异有统计学意义(尸3、于外对照组(O.32士0.45)%,差异有统计学意义妒4、.焦虑、抑郁.沮丧、愤怒.敌意、疲惫.惰性、困惑.迷茫)得分高于对照组,差异有统计学意义(P5、损伤;丫H2AX识别抗体流式细胞法;神经行为功能测试¨l浙江大学硕士学位论文英文摘要LymphocytesDNA-damageandNeurobehaVioraIEValuationofworkerswhoexposedtoHexyIhydrideMedicalSchoolofZhejiangUniversi够Postgraduate:HuLuIuTlutor:WhngJing【AbStract】objecti、,eStudying1),lnphocytesDNAdanlageofworkerSwho玳expoSedtoHexylhydrideusingnowcytomet叮觞say豫co6、gnizing丫H2AX,t0exploretllegenetictoxic时ofHexylhydride.Ex锄iningtlleneurobehaVioraJ劬ctionofworkerswhoexposedt0HexylhydrideusingneⅦ.0behaViomlteStsoRwarewhichCmne∞computerized,t0Explore锄dValidatetllepossibili够ofnervoussystemd锄agec锄SedbyHexyIhy“deoflowconcentratioIlS.MethodsTheperipheralbloodlymphoc”e7、swereobtainedf如m33worke瑙whoareoccupationaJlyexposedt0Hexylhydride(exposed訇的up)锄d17worke璐、Ⅳhoarenotexposedt0Hexylhy“iIeiIItlles锄ef-actory(iIlllercontr01)锄d52someresidentSwhoIIaVenotbeen0ccupationallycXposedt0adver
3、于外对照组(O.32士0.45)%,差异有统计学意义妒4、.焦虑、抑郁.沮丧、愤怒.敌意、疲惫.惰性、困惑.迷茫)得分高于对照组,差异有统计学意义(P5、损伤;丫H2AX识别抗体流式细胞法;神经行为功能测试¨l浙江大学硕士学位论文英文摘要LymphocytesDNA-damageandNeurobehaVioraIEValuationofworkerswhoexposedtoHexyIhydrideMedicalSchoolofZhejiangUniversi够Postgraduate:HuLuIuTlutor:WhngJing【AbStract】objecti、,eStudying1),lnphocytesDNAdanlageofworkerSwho玳expoSedtoHexylhydrideusingnowcytomet叮觞say豫co6、gnizing丫H2AX,t0exploretllegenetictoxic时ofHexylhydride.Ex锄iningtlleneurobehaVioraJ劬ctionofworkerswhoexposedt0HexylhydrideusingneⅦ.0behaViomlteStsoRwarewhichCmne∞computerized,t0Explore锄dValidatetllepossibili够ofnervoussystemd锄agec锄SedbyHexyIhy“deoflowconcentratioIlS.MethodsTheperipheralbloodlymphoc”e7、swereobtainedf如m33worke瑙whoareoccupationaJlyexposedt0Hexylhydride(exposed訇的up)锄d17worke璐、Ⅳhoarenotexposedt0Hexylhy“iIeiIItlles锄ef-actory(iIlllercontr01)锄d52someresidentSwhoIIaVenotbeen0ccupationallycXposedt0adver
4、.焦虑、抑郁.沮丧、愤怒.敌意、疲惫.惰性、困惑.迷茫)得分高于对照组,差异有统计学意义(P5、损伤;丫H2AX识别抗体流式细胞法;神经行为功能测试¨l浙江大学硕士学位论文英文摘要LymphocytesDNA-damageandNeurobehaVioraIEValuationofworkerswhoexposedtoHexyIhydrideMedicalSchoolofZhejiangUniversi够Postgraduate:HuLuIuTlutor:WhngJing【AbStract】objecti、,eStudying1),lnphocytesDNAdanlageofworkerSwho玳expoSedtoHexylhydrideusingnowcytomet叮觞say豫co6、gnizing丫H2AX,t0exploretllegenetictoxic时ofHexylhydride.Ex锄iningtlleneurobehaVioraJ劬ctionofworkerswhoexposedt0HexylhydrideusingneⅦ.0behaViomlteStsoRwarewhichCmne∞computerized,t0Explore锄dValidatetllepossibili够ofnervoussystemd锄agec锄SedbyHexyIhy“deoflowconcentratioIlS.MethodsTheperipheralbloodlymphoc”e7、swereobtainedf如m33worke瑙whoareoccupationaJlyexposedt0Hexylhydride(exposed訇的up)锄d17worke璐、Ⅳhoarenotexposedt0Hexylhy“iIeiIItlles锄ef-actory(iIlllercontr01)锄d52someresidentSwhoIIaVenotbeen0ccupationallycXposedt0adver
5、损伤;丫H2AX识别抗体流式细胞法;神经行为功能测试¨l浙江大学硕士学位论文英文摘要LymphocytesDNA-damageandNeurobehaVioraIEValuationofworkerswhoexposedtoHexyIhydrideMedicalSchoolofZhejiangUniversi够Postgraduate:HuLuIuTlutor:WhngJing【AbStract】objecti、,eStudying1),lnphocytesDNAdanlageofworkerSwho玳expoSedtoHexylhydrideusingnowcytomet叮觞say豫co
6、gnizing丫H2AX,t0exploretllegenetictoxic时ofHexylhydride.Ex锄iningtlleneurobehaVioraJ劬ctionofworkerswhoexposedt0HexylhydrideusingneⅦ.0behaViomlteStsoRwarewhichCmne∞computerized,t0Explore锄dValidatetllepossibili够ofnervoussystemd锄agec锄SedbyHexyIhy“deoflowconcentratioIlS.MethodsTheperipheralbloodlymphoc”e
7、swereobtainedf如m33worke瑙whoareoccupationaJlyexposedt0Hexylhydride(exposed訇的up)锄d17worke璐、Ⅳhoarenotexposedt0Hexylhy“iIeiIItlles锄ef-actory(iIlllercontr01)锄d52someresidentSwhoIIaVenotbeen0ccupationallycXposedt0adver
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