中成药治疗紧张型头痛的meta分析

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1、提要目的：通过Meta-分析的方法对国内中成药（以养血清脑颗粒为代表）治疗紧张型头痛的临床疗效进行客观评价，为临床合理选择及应用治疗措施提供客观的研究证据。方法：通过计算机全面检索有关养血清脑颗粒治疗紧张型头痛的临床试验文献，制定纳入与排除标准，筛选合格文献；采用Jadad评分标准评价合格研究的质量，对效应指标进行同质性检验、Meta-分析、漏斗图分析。2结果：共6篇文献进入Meta-分析，纳入研究总人数为495人，异质性检验Chi2=7.93，I=37%,P=0.16>0.05，纳入的研究文献具有同质性,采用固定效应模型(FixedEffectModel)进行Meta-分析，O

2、R=8.10，95%的CI为[4.73,13.88],两组临床疗效有效率差别具有统计学意义(P<0．00001)，菱形符号完全位于OR=1中线右侧。表明养血清脑颗粒的临床疗效优于西药。结论：Meta-分析的结果表明，中成药养血清脑颗粒治疗紧张型头痛确实有一定的疗效，然而由于纳入研究的病例数不足够大，文献质量较低，所以支持这一结论的证据有限，期待有高质量的临床随机对照试验来进一步证实本研究结果。关键词中医药；中成药；养血清脑颗粒；紧张型头痛；Meta-分析Meta-analysisofChinesePatentMedicineTreatmentonTension-TypeHeada

3、cheSpeciality:InternalMedicineofTCMAuthor:DongNingTutor:ChiefPhysicianHuZhiqiangAbstractObjectiveToassesstheefficiencyandsafetyofTraditionalChinesePatentMedicine(representedbyyangxueqingnaogranule)usedinthetreatmentofTension-TypeHeadachebyMeta-analysis.MethodsSearchedandcollectedclinicalexper

4、imentsinChinesepatentmedicineusedinthetension-typeheadacheroundlythroughinternet,establishedinclusioncriteriaandexclusioncriteria,filtratedqualifiedresearches,evaluatedthequalityofthequalifiedresearchesbyusingtheJadadstandardofperfection,madetestsforhomogeneity,Meta-analysis,funnelplotsanalys

5、is.Results6literaturesincluding495caseswerebroughtintoMeta-analysis.22HeterogeneitytestshowedthatChiwas7.93andIwas37%(P=0.16>0.05)indicatingthatthese6literaturesareingoodhomogeneity.SofixedeffectmodelwasusedandtheresultsshowedthatORwas8.10and95%CIwas[4.73,13.88](P<0.00001)andthediamondwasloca

6、tedintherightofinvalidline(OR=1)completelyindicatingthatChinesepatentmedicine(yangxueqingnaogranule)hassignificantdifferencewithwesternmedicineinthetreatmentoftension-typeheadache.ConclusionMeta-analysisresultshowsthatChinesepatentmedicineyangxueqingnaogranulefortension-typeheadachehascertain

7、curativeeffect.However,theevidenceisnotstrongenoughduetotheinsufficientcasesofclinicaltrials,andthelowqualitiesofliteratures.Thus,morerandomizedcontrolledtrailswithhighqualitiesareneededtofurtherassesstheeffect.KeywordsTraditionalChineseMedic