notch信号通路在膝骨关节炎软骨细胞凋亡中的作用分析

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1、万方数据weredestructedobviously,somehaveulcersandcracks，someregionsofarticularcartilageloss，revealingthesubchondralbone，alargeofosteophyteemergedonthemargin．thearticularcartilagesurfaceofinhibitiongroupsmooth，noswellingofjoints，cartilagemorecomplete，asmallamountofsofteningfo

2、cus，noulcersandcracks，noosteophyteformation；thesurfaceofarticularcartilageofcontrollesssmooth，thedamagedofarticularcartilagewaslight，asmallamountofosteophytewasformed，partofthecartilagehavecracks，evenasmallulcersappears．(2)stainedforHE：surfacelayerofcartilagesoftheactiva

3、torgrouphavealargeofdefectarea，disorganizedcellsandchondrocytesunclear,cartilagecellsreduced，tidallinesdisappeared，cartilaginousstructurescompletelydestroyed，partialregionFocalhyperplasia．；4layerofarticularcartilagestructureofinhibitiongroupclearlydistinguishable，Cartila

4、gedamageunconspicuous，surfaceregular,smoothandcomplete，cellsarrangedrule，tidallineclear；4-layerstructureofjointcartilageofcontrolCandiscriminate，cartilagecellsdecreasedinmostareas，cartilagecellsshoweddiffusehyperplasia，tidallinewasnotcomplete．Mankin'sscoreoftheactivatorg

5、roupwashigherthanthecontrolgroup，therewasasignificantdifferencebetweenthegroups(P<0．05)；Mankin’Sscoreoftheinhibitiongroupwaslowerthanthecontrolgroup，therewasasignificantdifferencebetweenthegroups(P<0．05)；Mankin。Sscoreoftheactivatorgroupwashigherthantheinhibitiongroup，the

6、rewasasignificantdifferencebetweenthegroups(P<0．05)．(3)Immunohistochemicalstaining：theNotchl、Bax．5．万方数据expressionofchondrocyteintheactivatorgroupwashigherthanthecontrolgroup，therewasasignificantdifferencebetweenthegroups(P

7、pwaslowerthanthecontrolgroup，therewasasignificantdifferencebetweenthegroups(P

8、econtrolgroup，therewasasignificantdifferencebetweenthegroups(P