光敏剂喜泊分对h22肝癌小鼠移植瘤的放射增敏作用与其机制分析

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1、英文摘要TheradiosensitizingeffectandmechanismofphotosensitizershematoporphyrinonH22hepatomamicexenograflsAbstractObjective：Primarylivercancer(Primarylivercancer)isthemostcommonmalignanttumorsofthedigestivesystem，accountingfor5．6％ofallthetotalnumberofcancers．Morethan50％oflivercancerworld

2、wideoccurinChina，themortalityrateranksfirsttwomalignancies，seriousthreattolifeandhealthofthepeople．Radiationtherapyisthecaseinorganpreservationtreatmentusedtocontrolalocaltumor,hasbecomeanimportantmeansoftreatmentoflivercancer．RadiotherapyaloneiSonlypartoftheradiation-sensitivetumor

3、shaveagoodeffect．buttherearestillavarietyoftumorstoradiationiSnotverysensitive．Radiationsensitizercanincreasethesensitivityoftumorcellstoradiationandradiationkillingrateoftumorcells，andenhancetheefficacyofradiotherapyhasbecomeanimportantresearchtopicincancerradiotherapy．hematoporphy

4、rin)，1，3，5，8,-tetramethyl一2，4一(0【-hydroxyethyl)一Porphine。6，7-twopropionicacid(C34H38N406)，wasapprovedbySFDAcountryaclassofchemicaldrugshematoporphyrinderivative．nedrugshaveaspecialaffinityfortumortissue，chemicalscanbeselectivelyconcentratedinthesiteofaction，48hafterapplicationofthec

5、oncentrationinthetumortissueiS10—30timesthenormaltissuethaninnormaltissueextendeddrain48-72h，or240hormore．Inaddition，hematoporphyrinofsolubleinwater，easeofadministration，theelectromagneticwaveCanbeexcitedtoplayaroleinkillingcancercellsandvitalorganswithoutapparenttoxicity，areexpecte

6、dtohavebettertumorradiosensitizationeffect．InthisexperimentwithH22hepatomacellsKunmingmousemodelforthestudy，researchhematoporphyrinofjointanti-tumorefficacyofdifferentdosesofradiotherapyprogramsandradiosensitizationeffect，setthecontrolgroup，hematoporphyringroup，radiotherapygroup，aco

7、mbinationtherapygroup，radiotherapygroup2，group2combinationtherapy，radiotherapythree-英文摘要groupscombinedtreatmentgroup3of8groupsingroup3of8groupsintumorvolume，qvalueandsensitizingfactoranalysis，tumorweightinhibitionrateofmicesurvival，pathologyresearchcomparingHEstaining，apoptosis，trea

8、tmentsideeffectsand