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1、提要目的:观察自拟中药调脂方治疗高脂血症的临床疗效及安全性。方法:将符合中医辨证标准的60例本病患者随机分成两组，治疗组30例服用自拟调脂方治疗，每日一剂，水煎400ml，分早晚两次服用，对照组口服舒降之(辛伐他汀片)，每次1片，每天一次。以8周为观察疗程,记录患者治疗前后中医证候积分指标及实验室指标变化情况,并进行比较。结果:1.两组治疗前后中医证候积分比较：两组治疗后的中医证候积分均明显低于治疗前,治疗后治疗组的中医证候积分明显低于对照组，统计学比较有显著性差异(P<0.01)；2.两组治疗前后临床疗效比较：两组患者治疗后总有效率分别为86.67%(治疗组)、83.
2、33%(对照组),统计学比较无显著性差异(P>0.05),说明两组疗效相当。3.两组患者治疗前后血脂改善比较：两组患者治疗后TC、TG、LDL-C,均较治疗前有降低,HDL-C较治疗前有所升高,同组治疗前后比较有统计学意义(P<0.05),治疗后治疗组在降血浆粘度､全血粘度方面较对照组有显著疗效,两组对比有显著性差异(P<0.05),而两组治疗前后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)比较,无显著性差异(p＞0.05)。结论:通过临床观察,自拟调脂方可以缓解和改善中医临床症状,调节脂质代谢紊乱。初步证明本法治疗高脂血症是安全、有效的。关键词高脂血症；
3、气血瘀滞；疏肝健脾活血法ClinicalStudyonTreatingHyperlipidemiawiththeMethodofLiver-discharging,Spleen-nourishingandBloodCirculationSpeciality：IternalMedicineofTraditionalChineseMedicineAuthor：GuoJialinTutor：prof.ZhangXueziAbstractObjective:Toobservetheclinicalefficacyofself-designedChinesemedicinalfo
4、rmulaeintreatinghyperlipidemiaanditssafety.Methods:SixtypatientsofPhlegm-DampSyndromeinHyperlipidemiaweredividedintotherapeuticgroup(30cases)andcontrolgroup(30cases)randomly.ThepatientsoftherapeuticgroupwerereceivedChinesemedicine,eachmedicinalpreparationwaterwillfrytwotimeswilltakejuice
5、200mlrespectively,afterthemix,altogether400mlsoonerorlatertodivide.ThepatientsofcontrolgroupweregivenZocor(simvastatin),eachone(20mg),onceaday.Thecourseoftreatmentlasted8weeks.ThescoresofTCMsyndromeindexandthechangesoflaboratoryparameterswereobservedandcomparedbeforeandaftertreatment.Res
6、ults:1.ThecomparisonofTCMpointsbetweentwogroupsbeforeandaftertreatment:Aftertreatment,TCMpointsofChinesemedicinesymptomsaresignificantlylowerthanbeforetreatment,andthereisstatisticallysignificantdifference(P<0.01).2.ClinicalComparisonoftwogroupsbeforeandaftertreatment:Aftertreatment,thet
7、otaleffectiverateis86.67%(treatmentgroup),83.33%(controlgroup),andthereisnostatisticallysignificantdifference(P>0.05),whichrevealstwogroupshavethesametreatment.3.ThecomparisonofbloodlipidsinTwogroupsbeforeandaftertreatment:thetwogroupsaftertreatmentinpatientswithTC,TG,LDL
