运动性骨关节损伤线粒体通路机制与干预初探

《运动性骨关节损伤线粒体通路机制与干预初探》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、physi0109icalsalinegroup：followedbytheIbuprofenadministeredgroup：intheHWTX—Iadministeredgroup，strongexpressionsofeachfactorproteincouldbeobserved，buttherewerefewerpositivecellsthanthephysi0109icalsalinegroupandtheIbuprofenadministeredgroup．(4)Byspectrophotometrydetection，theactivityofSOD、GSH—

2、PxwerethehighestintheHWTX—Iadministeredgroup，followedbytheIbuprofenadministeredgroup，andthelowestinthephysi0109icalsalinegroup：theactivityofCATthelowestinthephysi0109icalsalinegroup：theconcentofNOinserumthehighestinthephysi0109icalsalinegroup，followedbytheIbuprofenadministeredgroup，andthelowe

3、stintheHWTX—Iadministeredgroup．Conclusion：(1)TheadministrationofHWTX—IinspinalduramaterspaceuptheproteinexpressionsofBcl一2inmitochondrialapoptosispathwayanddowntheproteinexpressionsofBax、Caspase一3andCaspase一9，whichhasobviouslyprotectiveeffectsonratsarticularcartilagedamageinducedbyexercise-in

4、ducedarthritiS．(2)TheadministrationofHWTX—IinspinalduramaterspaceuptheactivityofSOD、CAT、GSH—PxanddownthecontentofNOinserum，whichcanobviouslyrelievethedamagerfreeradicalintheexercise—inducedarthritiSrats’articularcartilage．(3)Mitochondrialpathwayiscloselycorrelatedwithexercise—inducedarthritis

5、．ItisofimportanttheoreticalVsignificancetoexplainthemechanismofmitochondrialpathwayintheexercise—inducedarthritiS．(4)Themovementofcalciumhashighcorrelatedwiththedevelopmentofexercise—inducedarthritis．Ourresearchhasapproachedthemolecularmechanismofexercise—-inducedarthritisandtheefficacyofcalc

6、iumchannelblocker，itisforpreventionandcureofexercise—inducedarthritis．Keywords：Exercise—inducedarthritis：Mitochondrialpathway：Freeradical：HWTX—IVI缩略词表缩略词英文全称／中文译名Huwentoxin．IHwTx-I虎纹捕鸟蛛毒素．IBcl．2BaxCaspaseSODc妪。GSH—PxNOPCDPTPOFRApaf-ICytCB--celllymPhoma／leukemia··2B细胞淋巴瘤／8血病癌基因B-celllymPhoma-·

7、2associated—XB细胞淋巴瘤．2相关xCysteine-asparateProtease半胱氨酸蛋白酶Superoxidedismutase超氧化物歧化酶Catalase过氧化氢酶Glutathioneperoxidase谷胱甘肽过氧化物酶Nnitrogenmonoxide一氧化氮ProgramedCellDeath程序性细胞死亡PermeabilityTransitionPore线粒体通透性转换孔OxygenFreeRadical氧自由基ApoptosisProtea