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ID:33007624
大小:2.11 MB
页数:56页
时间:2019-02-19
《运动性骨关节损伤线粒体通路机制与干预初探》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、physi0109icalsalinegroup:followedbytheIbuprofenadministeredgroup:intheHWTX—Iadministeredgroup,strongexpressionsofeachfactorproteincouldbeobserved,buttherewerefewerpositivecellsthanthephysi0109icalsalinegroupandtheIbuprofenadministeredgroup.(4)Byspectrophotometrydetection,theactivityofSOD、GSH—
2、PxwerethehighestintheHWTX—Iadministeredgroup,followedbytheIbuprofenadministeredgroup,andthelowestinthephysi0109icalsalinegroup:theactivityofCATthelowestinthephysi0109icalsalinegroup:theconcentofNOinserumthehighestinthephysi0109icalsalinegroup,followedbytheIbuprofenadministeredgroup,andthelowe
3、stintheHWTX—Iadministeredgroup.Conclusion:(1)TheadministrationofHWTX—IinspinalduramaterspaceuptheproteinexpressionsofBcl一2inmitochondrialapoptosispathwayanddowntheproteinexpressionsofBax、Caspase一3andCaspase一9,whichhasobviouslyprotectiveeffectsonratsarticularcartilagedamageinducedbyexercise-in
4、ducedarthritiS.(2)TheadministrationofHWTX—IinspinalduramaterspaceuptheactivityofSOD、CAT、GSH—PxanddownthecontentofNOinserum,whichcanobviouslyrelievethedamagerfreeradicalintheexercise—inducedarthritiSrats’articularcartilage.(3)Mitochondrialpathwayiscloselycorrelatedwithexercise—inducedarthritis
5、.ItisofimportanttheoreticalVsignificancetoexplainthemechanismofmitochondrialpathwayintheexercise—inducedarthritiS.(4)Themovementofcalciumhashighcorrelatedwiththedevelopmentofexercise—inducedarthritis.Ourresearchhasapproachedthemolecularmechanismofexercise—-inducedarthritisandtheefficacyofcalc
6、iumchannelblocker,itisforpreventionandcureofexercise—inducedarthritis.Keywords:Exercise—inducedarthritis:Mitochondrialpathway:Freeradical:HWTX—IVI缩略词表缩略词英文全称/中文译名Huwentoxin.IHwTx-I虎纹捕鸟蛛毒素.IBcl.2BaxCaspaseSODc妪。GSH—PxNOPCDPTPOFRApaf-ICytCB--celllymPhoma/leukemia··2B细胞淋巴瘤/8血病癌基因B-celllymPhoma-·
7、2associated—XB细胞淋巴瘤.2相关xCysteine-asparateProtease半胱氨酸蛋白酶Superoxidedismutase超氧化物歧化酶Catalase过氧化氢酶Glutathioneperoxidase谷胱甘肽过氧化物酶Nnitrogenmonoxide一氧化氮ProgramedCellDeath程序性细胞死亡PermeabilityTransitionPore线粒体通透性转换孔OxygenFreeRadical氧自由基ApoptosisProtea
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